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Antimelanogenic and antioxidative properties of Bifidobacterium bifidum

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Abstract

Various skin hyperpigmentation disorders consist in accumulation and overproduction of melanin. In this report, we investigated the melanogenesis inhibitory and antioxidant effects of Bifidobacterium bifidum culture filtrate. The results revealed that B. bifidum culture filtrate effectively suppresses murine tyrosinase activity and decreases the amount of intracellular melanin in a dose-dependent manner. Additionally, the bacterial culture filtrate-scavenged DPPH and ABTS radicals, and shows potent-reducing power in a dose-dependent pattern. Our results expand the application of B. bifidum culture filtrate in the development and research of skin-whitening ingredients.

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Acknowledgments

The authors gratefully acknowledge financial support by grants from Ministry of Economic Affairs, R. O. C. (98-EC-17-A-17-S1-128 and S09900074-603).

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Authors and Affiliations

  1. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, ROC

    Huey-Chun Huang

  2. Department of Applied Cosmetology and Graduate Institute of Cosmetic Science, Hungkuang University, No. 34, Chung-Chie Road, Taichung County, Shalu, 43302, Taiwan, ROC

    Wen-Ying Huang, Shao-Hua Chiu, Hui-Ju Ke, Shu-wen Chiu, Sze-Yun Wu, Feng-Sheng Kuo & Tsong-Min Chang

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  1. Huey-Chun Huang
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Correspondence to Tsong-Min Chang.

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Huang, HC., Huang, WY., Chiu, SH. et al. Antimelanogenic and antioxidative properties of Bifidobacterium bifidum . Arch Dermatol Res 303, 527–531 (2011). https://doi.org/10.1007/s00403-011-1135-y

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  • DOI: https://doi.org/10.1007/s00403-011-1135-y

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