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Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk

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Abstract

Nitric oxide (NO) is a potent regulator of keratinocyte growth and differentiation that has been implicated in the pathogenesis of psoriasis (Ps). The NOS3 −786 T/C (SNP id rs2070744; http://www.ensembl.org), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease. The aim of this study was to determine whether the above-mentioned NOS3 variants contributed to the risk of Ps, and were associated with the risk for HT and CAD in these patients. A total of 368 patients with chronic plaque Ps and 400 healthy controls were genotyped for the NOS3 −786 T/C, intron 4 VNTR, and Glu298Asp polymorphisms. Carriers of the −786 C allele were significantly more frequent among the patients (p < 0.001). Carriers of the 4-repeats allele (45 + 44 genotypes) were also more frequent a (p < 0.001). No significant difference was found for the Glu298Asp polymorphism. None of the NOS3 variants was associated with Ht and CAD in our population. In conclusion, NOS3 gene polymorphism would be risk factors for developing Ps.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Dermatology II Department, University Hospital Central of Asturias (HUCA), 33007, Oviedo, Spain

    Pablo Coto-Segura, Albert Mas-Vidal & Jorge Santos-Juanes

  2. Molecular Genetics Department, University Hospital Central of Asturias (HUCA), Oviedo, Spain

    Eliecer Coto, Blanca Morales, Victoria Alvarez, Marta Díaz & Belén Alonso

Authors
  1. Pablo Coto-Segura
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  2. Eliecer Coto
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  3. Albert Mas-Vidal
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  4. Blanca Morales
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  5. Victoria Alvarez
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  6. Marta Díaz
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  7. Belén Alonso
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  8. Jorge Santos-Juanes
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Correspondence to Pablo Coto-Segura.

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Coto-Segura, P., Coto, E., Mas-Vidal, A. et al. Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk. Arch Dermatol Res 303, 445–449 (2011). https://doi.org/10.1007/s00403-011-1129-9

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  • DOI: https://doi.org/10.1007/s00403-011-1129-9

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