Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells
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Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.
KeywordsUVB Photodamage UVB-damaged cells Non-sunscreen protection Avocado extract Polyhydroxylated fatty alcohols
This study was supported in part by the Israel Ministry of Industry and Commerce. Mr. Sigmund Geller is thanked with pleasure for editing the manuscript.
- 1.Abe F, Nagafuji S, Okawa M, Kinjo J, Akahane H, Ogura T, Martinez-Alfaro AM, Reyes-Chilpa R (2005) Trypanocidal constituents in plants 5. Evaluation of some Mexican plants for their trypanocidal activity and active constituents in the seeds of Persea americana. Biol Pharm Bull 28:1314–1317PubMedCrossRefGoogle Scholar
- 27.Ramos-Jerz MR (2007) Phytochemical analysis of avocado seeds (Persea americana Mill., c.v. Hass). Cuvillier Verlag, GottingenGoogle Scholar