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Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells

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An Erratum to this article was published on 02 March 2011

Abstract

Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.

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Acknowledgments

This study was supported in part by the Israel Ministry of Industry and Commerce. Mr. Sigmund Geller is thanked with pleasure for editing the manuscript.

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Author notes

  1. Avi Schroeder

    Present address: Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA

  2. Alexandra Zanin-Zhorov

    Present address: School of Medicine, New York University, New York, NY, 10016, USA

Authors and Affiliations

  1. Polyol Biotech Ltd, Granot Initiative Center, 38100, D.N. Hefer, Israel

    Gennady Rosenblat, Shai Meretski & Joseph Segal

  2. School of Medicine, Hebrew University, 91120, Jerusalem, Israel

    Mark Tarshis

  3. Department of Dermatology, Hebrew University-Hadassah Medical Center, 91120, Jerusalem, Israel

    Gilead Lion, Arieh Ingber & Malka Hochberg

Authors
  1. Gennady Rosenblat
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  2. Shai Meretski
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Corresponding author

Correspondence to Gennady Rosenblat.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00403-011-1139-7

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Below is the link to the electronic supplementary material.

Figure 1

. Retention time (a) and GC-elution profile of polyhydroxylated fatty alcohols from avocado seed (b) and avocado pear (c). *Numbers in table correspond to the molecule marked with the same number in Fig.1 **retention time

Figure 2

. UV absorption spectrum of PFA

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Rosenblat, G., Meretski, S., Segal, J. et al. Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. Arch Dermatol Res 303, 239–246 (2011). https://doi.org/10.1007/s00403-010-1088-6

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  • DOI: https://doi.org/10.1007/s00403-010-1088-6

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