Skip to main content

Advertisement

SpringerLink
Log in

Apolipoprotein ε4 allele is associated with psoriasis severity

  • Short Communication
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls. Patients and controls were genotyped for the APOE-ε2/ε3/ε4 polymorphism, and allele and genotype frequencies were statistically compared between the two groups and between patients according to disease severity. Mean lipid values were also compared between the APOE genotypes. Allele and genotype frequencies did not differ between patients and controls. APOE-ε4 carriers were significantly more frequent in patients with severe Ps compared to controls (P = 0.003) and to non-severe Ps (P = 0.017). No significant difference in mean lipid values was found between the APOE genotypes. The APOE-ε4 allele could be a risk factor for developing a severe form of psoriasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Alvarez V, Alvarez R, Peña J et al (1999) Frequency of the APOE-4 allele in Alzheimer’s disease and its variation with age in Asturias (Spain). Med Clin 113(12):441–443

    Google Scholar 

  2. Batalla A, Alvarez R, Reguero JR et al (2000) Synergistic effect between apolipoprotein E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction. Clin Chem 46:1910–1915

    PubMed  CAS  Google Scholar 

  3. Campalani E, Allen MH, Fairhurst D et al (2006) Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol 154:345–352

    Article  PubMed  CAS  Google Scholar 

  4. Chasman DI, Kozlowski P, Zee RY, Kwiatkowski DJ, Ridker PM (2006) Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein. Genes Immun 7:211–219

    Article  PubMed  CAS  Google Scholar 

  5. Davignon J, Gregg RE, Sing CF (1988) Apolipoprotein E polymorphisms and atherosclerosis. Arteriosclerosis 8:1–21

    PubMed  CAS  Google Scholar 

  6. Errera FI, Silva ME, Yeh E, Maranduba CM, Folco B, Takahashi W, Pereira AC, Krieger JE, Passos-Bueno MR (2006) Effect of polymorphisms of the MTHFR and apoE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients. Braz J Med Biol Res 39(7):883–888

    Article  PubMed  CAS  Google Scholar 

  7. Eto M, Watanabe K, Ishii K (1986) Reciprocal effects of apolipoprotein E alleles (e2 and e4) on plasma lipid levels in normolipidemic subjects. Clin Genet 29:477–484

    Article  PubMed  CAS  Google Scholar 

  8. Fernandez Martinez M, Elcoroaristizabal Martin X, Galdos Alcelay LC et al (2009)The COMT Val158Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC Neurosci 10(1):125

    Google Scholar 

  9. Forte GI, Piccione M, Scola L, CriveXo A, Galfano C, Corsi MM, Chiapelli M, Candore G, GiuVre M, Verna R, Licastro F, Corsello G, Caruso C, Lio D (2007) Apo E genotypic frequencies among Down Syndrome Patients imply early unsuccessful aging for Apo E4 carriers. Rejuvenation Res 10(3):293–299

    Article  PubMed  CAS  Google Scholar 

  10. Furumoto H, Nakamura K, Imamura T et al (1997) Association of apolipoprotein allele epsilon 2 with psoriasis vulgaris in Japanese population. Arch Dermatol Res 289:497–500

    Article  PubMed  CAS  Google Scholar 

  11. Gomez-Coronado D, Alvarez JJ, Entrala A et al (1999) Apolipoprotein E polymorphism in men and women from a Spanish population: allele frequencies and influence on plasma lipids and apolipoproteins. Atherosclerosis 147:167–176

    Article  PubMed  CAS  Google Scholar 

  12. Jasinska-Myga B, Opala G, Goetz CG, Tustanowski J, Ochadlo S, Gorzkowska A, Tyrpa J (2007) Apo E gene polymorphism and plasma cholesterol level and Parkinson disease dementia. Arch Neurol 64(2):261–265

    Article  PubMed  Google Scholar 

  13. Jofre-Monseny L, Minihanane AM, Rimbach G (2008) Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 52:131–145

    Article  PubMed  CAS  Google Scholar 

  14. Karpouzis A, Caridha R, Tripsianis G, Michailidis C, Martinis G, Veletza SV (2009) Apolipoprotein E gene polymorphism in psoriasis. Arch Dermatol Res 301:405–410

    Article  PubMed  CAS  Google Scholar 

  15. Kayden HJ, Maschio F, Traber MG (1985) The secretion of apolipoprotein E by human monocyte-derived macrophages. Arch Biochem Biophys 239:388–395

    Article  PubMed  CAS  Google Scholar 

  16. Ladu MJ, Reardon C, Van Eldik L et al (2000) Lipoproteins in the central nervous system. Ann N Y Acad Sci 903:167–175

    Article  PubMed  CAS  Google Scholar 

  17. Laskowitz DT, Lee DM, Schmechel D et al (2000) Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res 41(4):613–620

    PubMed  CAS  Google Scholar 

  18. Mallbris L, Granath F, Hamsten A et al (2006) Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol 54:614–621

    Article  PubMed  Google Scholar 

  19. Mauri M, Sinforiani E, Bono G, Cittadella R, Quattrone A, Boller F, Nappi G (2006) Interaction between apoE4 and traumatic brain injury in patients with Alzheimer’s disease and mild cognitive impairment. Funct Neurol 21(4):223–228

    PubMed  Google Scholar 

  20. Mehta SG, Watts GD, Adamson JL, Hutton M, Umberger G, Xiong S, Ramdeen S, Lovel MA, Kimonis VE, Smith CD (2007) ApoE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia. Genet Med 9(1):9–13

    Article  PubMed  CAS  Google Scholar 

  21. Ng MC, Baum L, So WY, Lam VK, Wang Y, Poon E, Tomlinson B, Cheng S, Lindpainter K, Chan JC (2006) Association of lipoprotein lipase S447x, apoE exon 4 and apo C3-455T-C polymorphism on the susceptibility of diabetic nephropathy. Clin Genet 70(1):20–28

    Article  PubMed  CAS  Google Scholar 

  22. Niu W, Guo X, Su Y, Qiu C (2007) ApoE gene and LDL receptor gene polymorphisms in dyslipidemias associated essential hypertension. J Hum Hypertens 21(4):337–339

    PubMed  CAS  Google Scholar 

  23. Panegyres PK, Beilby J, Bulsara M, Toufexis K, Wong C (2006) A study of potential interactive genetic factors in Huntington’s disease. Eur Neurol 55(4):189–192

    Article  PubMed  Google Scholar 

  24. Parmenter BA, Denney DR, Lynch SG, Middleton LS, Harlan LM (2007) Cognitive impairment in patients with multiple sclerosis: association with the apoE gene and promoter polymorphism. Mult Scler 13(1):25–32

    Article  PubMed  CAS  Google Scholar 

  25. Pedro-Botet J, Sentí M, Nogués X (1992) Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Stroke 23(11):1556–1562

    PubMed  CAS  Google Scholar 

  26. Poirier J, Davignon J, Bouthillier D et al (1993) Apolipoprotein E polymorphism and Alzheimer’s disease. Lancet 342:697–699

    Article  PubMed  CAS  Google Scholar 

  27. Rall SC, Weisgraber KH, Mahley RW (1982) Human apolipoprotein E: the complete amino acid sequence. J Biol Chem 257:4171–4178

    PubMed  CAS  Google Scholar 

  28. Riddell DR, Graham A, Owen JS (1997) Apolipoprotein E inhibits platelet aggregation through the L-arginine: nitric oxide pathway. Implications for vascular disease. J Biol Chem 272:89–95

    Article  PubMed  CAS  Google Scholar 

  29. Seishima M, Seishima M, Hua S, Abe A, Noma A (1995) Apo E phenotype does not contribute to the pathogenesis of psoriasis. Br J Dermatol 132(1):169–171

    Article  PubMed  CAS  Google Scholar 

  30. Sing CF, Davignon J (1985) Role of the apolipoprotein E polymorphism in determining normal plasma and lipid and lipoprotein variation. Am J Hum Genet 37:268–285

    PubMed  CAS  Google Scholar 

  31. Stannard AK, Riddell DR, Sacre SM et al (2001) Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. J Biol Chem 276:46011–46016

    Article  PubMed  CAS  Google Scholar 

  32. Tziakas DN, Chalikias GK, Antonoglou CO et al (2006) Apolipoprotein E genotype and circulating interleukin-10 levels in patients with stable and unstable coronary artery disease. J Am Coll Cardiol 48:2471–2481

    Article  PubMed  CAS  Google Scholar 

  33. Zeleny M, Swertfeger DK, Weisgraber KH et al (2002) Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry 41:11820–11823

    Article  PubMed  CAS  Google Scholar 

  34. Waugh WH (2006) Apo E gene and macular degeneration. Ophthalmology 113(10):1888–1889

    Article  PubMed  Google Scholar 

  35. Wenham PR, Price WH, Blundell G (1991) Apolipoprotein E genotyping by one-stage PCR. Lancet 337:1158–1159

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest statement

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Dermatology II Department, Hospital Universitario Central de Asturias (HUCA), Celestino Villamil s/n, 33006, Oviedo, Spain

    Pablo Coto-Segura, Javier Soto-Sánchez & Jorge Santos-Juanes

  2. Molecular Genetics Department, HUCA, Oviedo, Spain

    Eliecer Coto, Victoria Alvarez, Blanca Morales & A. I. Corao

Authors
  1. Pablo Coto-Segura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eliecer Coto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Victoria Alvarez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Blanca Morales
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Javier Soto-Sánchez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. I. Corao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jorge Santos-Juanes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jorge Santos-Juanes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Coto-Segura, P., Coto, E., Alvarez, V. et al. Apolipoprotein ε4 allele is associated with psoriasis severity. Arch Dermatol Res 302, 145–149 (2010). https://doi.org/10.1007/s00403-009-1002-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-009-1002-2

Keywords

Search

Navigation