Archives of Dermatological Research

, Volume 302, Issue 2, pp 71–83 | Cite as

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

  • Joi A. Nichols
  • Santosh K. KatiyarEmail author
Mini Review


Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.


Interleukin DNA repair Antioxidant Anti-inflammation Polyphenols Ultraviolet radiation Cyclooxygenase-2 







Grape seed proanthocyanidins


Green tea polyphenols




Nucleotide excision repair


Nuclear factor-kappaB





The work reported from Dr Katiyar’s laboratory was supported by the funds from National Institutes of Health (CA104428, AT002536) and Veteran Affairs Merit Review Award (S.K. Katiyar). The content of this article does not necessarily reflect the views or policies of the funding sources. Grateful thanks are also due to our former and current colleagues and postdoctoral fellows for their outstanding contributions.


  1. 1.
    Adhami VM, Afaq F, Ahmad N (2003) Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia 5:74–82PubMedGoogle Scholar
  2. 2.
    Afaq F, Adhami VM, Ahmad N (2003) Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 186:28–37PubMedCrossRefGoogle Scholar
  3. 3.
    Aziz MH, Afaq F, Ahmad N (2005) Prevention of ultraviolet B radiation—damage by resveratrol in mouse skin is mediated via modulation in Survivin. Photochem Photobiol 81:25–31PubMedCrossRefGoogle Scholar
  4. 4.
    Aziz MH, Kumar R, Ahmad N (2003) Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol 23:17–28PubMedGoogle Scholar
  5. 5.
    Bachelor MA, Bowden GT (2004) UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol 14:131–138PubMedCrossRefGoogle Scholar
  6. 6.
    Baliga MS, Katiyar SK (2006) Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem Photobiol Sci 5:243–253PubMedCrossRefGoogle Scholar
  7. 7.
    Brash DE, Rudolph JA, Simon JA et al (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 88:10124–10128PubMedCrossRefGoogle Scholar
  8. 8.
    Buckman SY, Gresham A, Hale P et al (1998) COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis 19:723–729PubMedCrossRefGoogle Scholar
  9. 9.
    Camouse MM, Domingo DS, Swain FR et al (2009) Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin. Exp Dermatol 18:522–526PubMedCrossRefGoogle Scholar
  10. 10.
    Chapple KS, Cartwright EJ, Hawcroft G et al (2000) Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am J Pathol 156:545–553PubMedGoogle Scholar
  11. 11.
    Chatterjee ML, Agarwal R, Mukhtar H (1996) Ultraviolet B radiation-induced DNA lesions in mouse epidermis: an assessment using a novel 32P-postlabelling technique. Biochem Biophys Res Commun 229:590–595PubMedCrossRefGoogle Scholar
  12. 12.
    Cowen EW, Billingsley EM (1999) Awareness of skin cancer by kidney transplant patients. J Am Acad Dermatol 40:697–701PubMedCrossRefGoogle Scholar
  13. 13.
    de Gruijl FR, van der Leun JC (1994) Estimate of the wavelength dependency of ultraviolet carcinogenesis in humans and its relevance to the risk assessment of stratospheric ozone depletion. Health Phys 67:319–325PubMedGoogle Scholar
  14. 14.
    de Gruijl FR (2000) Photocarcinogenesis: UVA vs UVB. Singlet oxygen, UVA, and ozone. Methods Enzymol 319:359–366PubMedCrossRefGoogle Scholar
  15. 15.
    DiGiovanna JJ (1998) Posttransplantation skin cancer: scope of the problem, management and role for systemic retinoid chemoprevention. Transplant Proc 30:2771–2775PubMedCrossRefGoogle Scholar
  16. 16.
    DiGiovanni J (1992) Multistage carcinogenesis in mouse skin. Pharmacol Ther 54:63–128PubMedCrossRefGoogle Scholar
  17. 17.
    Donawho CK, Kripke ML (1991) Evidence that the local effect of ultraviolet radiation on the growth of murine melanomas is immunologically mediated. Cancer Res 51:4176–4181PubMedGoogle Scholar
  18. 18.
    Douki T, Reynaud-Angelin A, Cadet J et al (2003) Bipyrimidine photoproducts rather than oxidative lesions are the main type of DNA damage involved in the genotoxic effect of solar UVA radiation. Biochemistry 42:9221–9226PubMedCrossRefGoogle Scholar
  19. 19.
    Elmets CA, Singh D, Tubesing K et al (2001) Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol 44:425–432PubMedCrossRefGoogle Scholar
  20. 20.
    Fortina AB, Caforio AL, Piaserico S (2000) Skin cancer in heart transplant recipients: frequency and risk factor analysis. J Heart Lung Transplant 19:249–255PubMedCrossRefGoogle Scholar
  21. 21.
    Gu M, Dhanalakshmi S, Singh RP et al (2004) Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res 64:6349–6356CrossRefGoogle Scholar
  22. 22.
    Gu M, Dhanalakshmi S, Singh RP et al (2005) Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Cancer Epidemiol Biomarkers Prev 14:1344–1349PubMedCrossRefGoogle Scholar
  23. 23.
    Halliwell B, Gutteridge JMC, Cross CE (1992) Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 119:598–620PubMedGoogle Scholar
  24. 24.
    Hojo M, Morimoto T, Maluccio M (1999) Cyclosporin induces cancer progression by a cell-autonomous mechanism. Nature (Lond) 397:530–534CrossRefGoogle Scholar
  25. 25.
    Hruza LL, Pentland AP (1993) Mechanisms of UV-induced inflammation. J Invest Dermatol 100:35S–41SPubMedCrossRefGoogle Scholar
  26. 26.
    Huang CC, Fang JY, Wu WB et al (2005) Protective effects of (−)-epicatechin-3-gallate on UVA-induced damage in HaCaT keratinocytes. Arch Dermatol Res 296:473–481PubMedCrossRefGoogle Scholar
  27. 27.
    Huang CC, Wu WB, Fang JY, Chiang HS, Chen SK, Chen BH, Chen YT, Hung CF (2007) (−)-Epicatechin-3-gallate, a green tea polyphenol is a potent agent against UVB-induced damage in HaCaT keratinocytes. Molecules 12:1845–1858PubMedCrossRefGoogle Scholar
  28. 28.
    Ichihashi M, Ueda M, Budiyanto A (2003) UV-induced skin damage. Toxicology 189:21–39PubMedCrossRefGoogle Scholar
  29. 29.
    Jang M, Cai L, Udeani GO et al (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220PubMedCrossRefGoogle Scholar
  30. 30.
    Jeon HY, Kim JK, Kim WG et al (2009) Effects of oral epigallocatechin gallate supplementation on the minimal erythema dose and UV-induced skin damage. Skin Pharmacol Physiol 22:137–14131PubMedCrossRefGoogle Scholar
  31. 31.
    Katiyar SK (2002) Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol 21:1213–1222PubMedGoogle Scholar
  32. 32.
    Katiyar SK (2005) Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects. Int J Oncol 26(1):169–176PubMedGoogle Scholar
  33. 33.
    Katiyar SK, Afaq F, Azizuddin K et al (2001) Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (−)-epigallocatechin-3-gallate. Toxicol Appl Pharmacol 176:107–110CrossRefGoogle Scholar
  34. 34.
    Katiyar SK, Afaq F, Perez A et al (2001) Green tea polyphenol (−)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis 22:287–294PubMedCrossRefGoogle Scholar
  35. 35.
    Katiyar SK, Agarwal R, Mukhtar H (1994) Inhibition of spontaneous and photo-enhanced lipid peroxidation in mouse epidermal microsomes by epicatechin derivatives from green tea. Cancer Lett 79:61–66PubMedCrossRefGoogle Scholar
  36. 36.
    Katiyar SK, Ahmad N, Mukhtar H (2000) Green tea and skin. Arch Dermatol 136:989–994PubMedCrossRefGoogle Scholar
  37. 37.
    Katiyar SK, Challa A, McCormick TS et al (1999) Prevention of UVB-induced immunosuppression in mice by green tea polyphenol (−)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production. Carcinogenesis 20:2117–2124PubMedCrossRefGoogle Scholar
  38. 38.
    Katiyar SK, Elmets CA (2001) Green tea polyphenolic antioxidants and skin photoprotection. Int J Oncol 18:1307–1313PubMedGoogle Scholar
  39. 39.
    Katiyar SK, Elmets CA, Agarwal R et al (1995) Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols. Photochem Photobiol 62:855–861PubMedGoogle Scholar
  40. 40.
    Katiyar SK, Korman NJ, Mukhtar H et al (1997) Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J Natl Cancer Inst 89:556–566PubMedCrossRefGoogle Scholar
  41. 41.
    Katiyar SK, Matsui MS, Elmets CA et al (1999) Polyphenolic antioxidant (−)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem Photobiol 69:148–153PubMedGoogle Scholar
  42. 42.
    Katiyar SK, Matsui MS, Mukhtar H (2000) Kinetics of UV light-induced cyclobutane pyrimidine dimers in human skin in vivo: an immunohistochemical analysis of both epidermis and dermis. Photochem Photobiol 72:788–793PubMedCrossRefGoogle Scholar
  43. 43.
    Katiyar SK, Mukhtar H (2001) Green tea polyphenol (−)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen presenting cells and oxidative stress. J Leukoc Biol 69:719–726PubMedGoogle Scholar
  44. 44.
    Katiyar SK, Bergamo BM, Vayalil PK, Elmets CA (2001) Green tea polyphenols: DNA photodamage and photoimmunology. J Photochem Photobiol B 65:109–114PubMedCrossRefGoogle Scholar
  45. 45.
    Katiyar SK, Mukhtar H (1997) Tea antioxidants in cancer chemoprevention. J Cell Biochem Suppl 27:59–67PubMedCrossRefGoogle Scholar
  46. 46.
    Katiyar SK, Perez A, Mukhtar H (2000) Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA. Clinical Cancer Res 6:3864–3869Google Scholar
  47. 47.
    Kim J, Hwang J-S, Cho Y-K et al (2001) Protective effects of (−)-epigallocatechin-3-gallate on UVA- and UVB-induced skin damage. Skin Pharmacol Appl Skin Physiol 14:11–19PubMedGoogle Scholar
  48. 48.
    Kinlen L, Sheil A, Peta J (1979) Collaborative United Kingdom–Australia study of cancer in patients treated with immunosuppressive drugs. Br Med J 1461–1466Google Scholar
  49. 49.
    Klebanoff SJ (1988) In: Gallin JI, Goldstein IM, Snyderman R (eds) Inflammation: basic principles and clinical correlates. Raven Press, New York, pp. 391–444Google Scholar
  50. 50.
    Kligman LH, Akin FJ, Kligman AM (1980) Sunscreens prevent ultraviolet photocarcinogenesis. J Am Acad Dermatol 3:30–35PubMedCrossRefGoogle Scholar
  51. 51.
    Kripke ML (1990) Photoimmunology. Photochem Photobiol 52:919–924PubMedCrossRefGoogle Scholar
  52. 52.
    Kripke ML, Cox PA, Alas LG et al (1992) Pyrimidine dimers in DNA initiated systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci USA 89:7516–7520PubMedCrossRefGoogle Scholar
  53. 53.
    Krutmann J (2001) The role of UVA rays in skin aging. Eur J Dermatol 11:170–171PubMedGoogle Scholar
  54. 54.
    Langenbach R, Loftin CD, Lee C et al (1999) Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis. Ann N Y Acad Sci 889:52–61PubMedCrossRefGoogle Scholar
  55. 55.
    Li YH, Wu Y, Wei HC et al (2009) Protective effects of green tea extracts on photoaging and photoimmunosuppression. Skin Res Technol 15:338–345PubMedCrossRefGoogle Scholar
  56. 56.
    Manach C, Scalbert A, Morand C et al (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727–747PubMedGoogle Scholar
  57. 57.
    Mantena SK, Katiyar SK (2006) Grape seed proanthocyanidins inhibit UV radiation-induced oxidative stress and activation of MAPK and NF-κB signaling in human epidermal keratinocytes. Free Radic Biol Med 40:1603–1614PubMedCrossRefGoogle Scholar
  58. 58.
    Maziere C, Dantin F, Dubois F et al (2000) Biphasic effect of UVA radiation on STAT1 activity and tyrosine phosphorylation in cultured human keratinocytes. Free Radic Biol Med 28:1430–1437PubMedCrossRefGoogle Scholar
  59. 59.
    Meeran SM, Akhtar S, Katiyar SK (2009) Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol 129:1258–1270PubMedCrossRefGoogle Scholar
  60. 60.
    Meeran SM, Katiyar SK (2008) Proanthocyanidins inhibit mitogenic and survival-signaling in vitro and tumor growth in vivo. Front Biosci 13:887–897PubMedCrossRefGoogle Scholar
  61. 61.
    Meeran SM, Mantena SK, Elmets CA et al (2006) (−)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair. Cancer Res 66:5512–5520PubMedCrossRefGoogle Scholar
  62. 62.
    Meeran SM, Mantena SK, Meleth S et al (2006) Interleukin-12-deficient mice are at greater risk of ultraviolet radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol Cancer Ther 5:825–832PubMedCrossRefGoogle Scholar
  63. 63.
    Meeran SM, Mantena SK, Katiyar SK (2006) Prevention of ultraviolet radiation-induced immunosuppression by (−)-epigallocatechin-3-gallate in mice is mediated through interleukin 12-dependent DNA repair. Clin Cancer Res 12:2272–2280PubMedCrossRefGoogle Scholar
  64. 64.
    Meunier L, Raison-Peyron N, Meynadier J (1998) UV-induced immunosuppression and skin cancers. Rev Med Interne 19:247–254PubMedCrossRefGoogle Scholar
  65. 65.
    Miller DL, Weinstock MA (1994) Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 30:774–778PubMedCrossRefGoogle Scholar
  66. 66.
    Mittal A, Elmets CA, Katiyar SK (2003) Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24:1379–1388PubMedCrossRefGoogle Scholar
  67. 67.
    Mittal A, Piyathilake C, Hara Y et al (2003) Exceptionally high protection of photocarcinogenesis by topical application of (−)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylation. Neoplasia 5:555–565PubMedGoogle Scholar
  68. 68.
    Mnich CD, Hoek KS, Virkki LV et al (2009) Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls. Exp Dermatol 18:69–77PubMedCrossRefGoogle Scholar
  69. 69.
    Moore JO, Wang Y, Stebbins WG et al (2006) Photoprotective effect of isoflavone genistein on ultraviolet B induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis. Carcinogenesis 27:1627–1635PubMedCrossRefGoogle Scholar
  70. 70.
    Morley N, Clifford T, Salter L et al (2005) The green tea polyphenol (−)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage. Photodermatol Photoimmunol Photomed 21:15–22PubMedCrossRefGoogle Scholar
  71. 71.
    Mukhtar H, Elmets CA (1996) Photocarcinogenesis: mechanisms, models and human health implications. Photochem Photobiol 63:355–447CrossRefGoogle Scholar
  72. 72.
    Otley CC, Pittelkow MR (2000) Skin cancer in liver transplant recipients. Liver Transpl 6:253–262PubMedGoogle Scholar
  73. 73.
    Park K, Lee JH (2008) Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway. Oncol Rep 19:413–417PubMedGoogle Scholar
  74. 74.
    Parrish JA (1983) Photoimmunology. Adv Exp Med Biol 160:91–108PubMedGoogle Scholar
  75. 75.
    Reagan-Shaw S, Nihal M, Ahmad N (2007) Dose translation from animal to human studies revisited. FASEB J 22:659–661PubMedCrossRefGoogle Scholar
  76. 76.
    Runger TM (1999) Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer. A short review. Photodermatol Photoimmunol Photomed 15:212–216PubMedCrossRefGoogle Scholar
  77. 77.
    Scalbert A, Morand C, Manach C et al (2002) Absorption and metabolism of polyphenols in the gut and impact on health. Biomed Pharmacother 56:276–282PubMedCrossRefGoogle Scholar
  78. 78.
    Schwarz A, Maeda A, Gan D et al (2008) Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12. Photochem Photobiol 84:350–355PubMedCrossRefGoogle Scholar
  79. 79.
    Schwarz A, Maeda A, Kernebeck K et al (2005) Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 201:173–179PubMedCrossRefGoogle Scholar
  80. 80.
    Schwarz A, Stander S, Berneburg M et al (2002) Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 4:26–31PubMedCrossRefGoogle Scholar
  81. 81.
    Scotto J, Fears TR (1978) Skin cancer epidemiology: research needs. Natl Cancer Inst Monogr 50:169–177PubMedGoogle Scholar
  82. 82.
    Sharma SD, Meeran SM, Katiyar SK (2007) Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ther 6:995–1005PubMedCrossRefGoogle Scholar
  83. 83.
    Stadtman ER (2001) Protein oxidation in aging and age-related diseases. Ann N Y Acad Sci 928:22–38PubMedCrossRefGoogle Scholar
  84. 84.
    Strom S (1996) In: Weber R, Miller M, Goepfert H (eds) Basal and squamous cell skin cancers of the head and neck, Williams and Wilkins, Baltimore, pp 1–7Google Scholar
  85. 85.
    Taylor CR, Stern RS, Leyden JJ et al (1990) Gilchrest, photoaging/photodamage and photoprotection. J Am Acad Dermatol 22:1–15PubMedCrossRefGoogle Scholar
  86. 86.
    Timares L, Katiyar SK, Elmets CA (2008) DNA damage, apoptosis and Langerhans cells-activators of UV-induced immune tolerance. Photochem Photobiol 84:422–436PubMedCrossRefGoogle Scholar
  87. 87.
    Ullrich SE (1995) Potential for immunotoxicity due to environmental exposure to ultraviolet radiation. Hum Exp Toxicol 14:89–91PubMedCrossRefGoogle Scholar
  88. 88.
    Urbach F (1991) Incidences of nonmelanoma skin cancer. Dermatol Clin 9:751–755PubMedGoogle Scholar
  89. 89.
    Vanderveen EE, Grekin RC, Swanson NA et al (1986) Arachidonic acid metabolites in cutaneous carcinomas. Arch Dermatol 122:407–412PubMedCrossRefGoogle Scholar
  90. 90.
    Vayalil PK, Elmets CA, Katiyar SK (2003) Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin. Carcinogenesis 24:927–936PubMedCrossRefGoogle Scholar
  91. 91.
    Vayalil PK, Mittal A, Hara Y et al (2004) Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol 122:1480–1487PubMedCrossRefGoogle Scholar
  92. 92.
    Wang SQ, Setlow R, Berwick M (2001) Ultraviolet A and melanoma: a review. J Am Acad Dermatol 44:837–846PubMedCrossRefGoogle Scholar
  93. 93.
    Wang Y, Zhang X, Lebwohl M et al (1998) Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein. Carcinogenesis 19:649–654PubMedCrossRefGoogle Scholar
  94. 94.
    Wang ZY, Huang MT, Ferraro T et al (1992) Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res 52:1162–1170PubMedGoogle Scholar
  95. 95.
    Wang ZY, Huang MT, Ho CT et al (1992) Inhibitory effect of green tea on the growth of established skin papillomas in mice. Cancer Res 52:6657–6665PubMedGoogle Scholar
  96. 96.
    Wei H, Ca Q, Rahn R et al (1998) DNA structural integrity and base composition affect ultraviolet light-induced oxidative DNA damage. Biochemistry 37(18):6485–6490PubMedCrossRefGoogle Scholar
  97. 97.
    Wei H, Saladi R, Lu Y et al (2003) Isoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr 133(11 Suppl 1):3811S–3819SPubMedGoogle Scholar
  98. 98.
    Wei H, Zhang X, Zhao JF et al (1999) Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green and black teas. Free Radic Biol Med 26:1427–1435PubMedCrossRefGoogle Scholar
  99. 99.
    Yang CS, Wang ZY (1993) Tea and cancer. J Natl Cancer Inst 85:1038–1049PubMedCrossRefGoogle Scholar
  100. 100.
    Yarosh D, Alas LG, Yee V et al (1992) Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res 52:4227–4231PubMedGoogle Scholar
  101. 101.
    Yoshikawa T, Rae V, Bruins-Slot W (1990) Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J Invest Dermatol 95:530–536PubMedCrossRefGoogle Scholar
  102. 102.
    Zhao JF, Zhang YJ, Jin XH et al (1999) Green tea protects against psoralen plus ultraviolet A-induced photochemical damage to skin. J Invest Dermatol 113:1070–1075PubMedCrossRefGoogle Scholar
  103. 103.
    Zi SX, Ma HJ, Li Y et al (2009) Oligomeric proanthocyanidins from grape seeds effectively inhibit ultraviolet-induced melanogenesis of human melanocytes in vitro. Int J Mol Med 23:197–204PubMedGoogle Scholar
  104. 104.
    Ziegler A, Jonason AS, Leffell DJ et al (1994) Sunburn and p53 in the onset of skin cancer. Nature 372:773–776PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Clinical Nutrition Research CenterUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.Birmingham Veterans Administration Medical CenterBirminghamUSA

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