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Genetic evidence for involvement of the IL23 pathway in Thai psoriatics

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Abstract

A recent genome-wide association analysis of psoriasis identified IL12B and IL23R as significantly associated with psoriasis. Here we report association test results of a Thai cohort consisting of 206 psoriasis cases and 114 controls. The IL23R SNPs rs7530511 and rs11209026, and IL12B SNPs rs3212227 and rs6887695 were genotyped using Taqman assays. Data were analyzed using a logistic regression model for linear trend of association. One of the IL23R markers, rs7530511, was marginally significant (P = 0.017). The other IL23R marker, rs11209026, was not polymorphic. One of the IL12B markers, rs3212227, showed significant association with psoriasis (OR = 1.64, P = 0.0058) while the other, rs6887695, did not (OR = 1.29, P = 0.12). Haplotype analysis of the two IL12B SNPs yielded highly significant association (P = 0.00081, OR = 1.73). These results showed that IL12B is an important genetic factor in psoriasis pathogenesis in the Thai population, with an association strong enough to yield significant confirmatory evidence using a modest sample size. Together with previously reported evidence for IL12B association in Caucasian, Japanese, and Chinese psoriatics, our results support the hypothesis that genes encoding components of the IL23-mediated inflammatory pathway are important determinants of psoriasis pathogenesis across multiple racial groups.

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Acknowledgments

We thank the psoriasis patients and controls who volunteered to participate in this study. This work was supported by awards (R01 AR042742 and R01 AR050511) from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, and by the Babcock Memorial Trust.

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Authors and Affiliations

  1. Department of Dermatology, University of Michigan, 3430 CCGC, Box 5932, 1500 East Medical Center Dr., Ann Arbor, MI, 48109-5932, USA

    Rajan P. Nair, Philip E. Stuart & Trilokraj Tejasvi

  2. Institute of Dermatology, Bangkok, Thailand

    Preya Kullavanijaya & Prisana Kullavanijaya

  3. Department of Dermatology, University of Michigan, 1910 TC, Box 5314, 1500 East Medical Center Dr., Ann Arbor, MI, 48109-5314, USA

    John J. Voorhees

  4. Department of Dermatology, University of Michigan, 3312 CCGC, Box 5932, 1500 East Medical Center Dr., Ann Arbor, MI, 48109-5932, USA

    James T. Elder

  5. Department of Dermatology, Ann Arbor VA Health System, Ann Arbor, MI, USA

    James T. Elder

Authors
  1. Rajan P. Nair
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  2. Philip E. Stuart
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  3. Preya Kullavanijaya
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  4. Prisana Kullavanijaya
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  5. Trilokraj Tejasvi
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  6. John J. Voorhees
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  7. James T. Elder
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Corresponding author

Correspondence to Rajan P. Nair.

Additional information

Rajan P. Nair and Philip E. Stuart have contributed equally to this work.

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Nair, R.P., Stuart, P.E., Kullavanijaya, P. et al. Genetic evidence for involvement of the IL23 pathway in Thai psoriatics. Arch Dermatol Res 302, 139–143 (2010). https://doi.org/10.1007/s00403-009-0986-y

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  • DOI: https://doi.org/10.1007/s00403-009-0986-y

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