Hair growth promoting activity of Eclipta alba in male albino rats

Abstract

Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Eclipta alba Hassk. is a well-known Ayurvedic herb with purported claims of hair growth promotion. In the reported work attempts were undertaken to evaluate petroleum ether and ethanol extract of E. alba Hassk. for their effect on promoting hair growth in albino rats. The extracts were incorporated into oleaginous cream (water in oil cream base) and applied topically on shaved denuded skin of albino rats. The time (in days) required for hair growth initiation as well as completion of hair growth cycle was recorded. Minoxidil 2% solution was applied topically and served as positive control for comparison. Hair growth initiation time was significantly reduced to half on treatment with the extracts, as compared to control animals. The time required for complete hair growth was also significantly reduced. Quantitative analysis of hair growth after treatment with petroleum ether extract (5%) exhibited greater number of hair follicles in anagenic phase (69 ± 4) which were higher as compared to control (47 ± 13). The result of treatment with 2 and 5% petroleum ether extracts were better than the positive control minoxidil 2% treatment.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. 1.

    Adhirajan N, Dixit VK, Gowri C (2001) Development and evaluation of herbal formulations for hair growth. Indian Drugs 38(11):559–563

    Google Scholar 

  2. 2.

    Adhirajan N, Ravi Kumar T, Shanmugasundaram N, Mary B (2003) In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. J Ethnopharmacol 88:235–239

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    Chopra RN, Nayer SL, Chopra IC (1986) Glossary of Indian medicinal plants, Publication and Information Directorate, CSIR, New Delhi: 85

  4. 4.

    Chunekar KC, Hota NP (eds) (1986) Plants of Bhavprakash, vol 1. National Academy of Ayurveda, New Delhi: 126

  5. 5.

    Hoffman R, Happle R (2000) Current understanding of androgenetic alopecia. Part II: clinical aspects and treatment. Eur J of Dermatol 10(5):410–417

    Google Scholar 

  6. 6.

    Kamimura A, Procyanidin Takahashi T. (2005) B-2 extracted from apples, promotes hair growth: a laboratory study. Br J of Dermatol 146:41–51

    Article  Google Scholar 

  7. 7.

    Libecco JF, Bergfeld WF (2004) Finasteride in the treatment of alopecia. Expert Opin Pharmacother 5(4):933–940

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Prager N, Bickett K, French N, Marcovici G (2002) A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-α-reductase in the treatment of androgenetic alopecia. J Alt Compl Med 8(2):143–152

    Article  Google Scholar 

  9. 9.

    Pharmacopoeia of India (1996) vol II. Ministry of Health, New Delhi: 90–99

  10. 10.

    Roy RK, Thakur M, Dixit VK (2006) Effect of Cuscuta reflexa Roxb. on hair growth activity of albino rats. Indian Drugs 43(12):951–956

    Google Scholar 

  11. 11.

    Roy RK, Thakur M, Dixit VK (2007) Development and performance evaluation of herbal formulation for hair growth promoting activity. J Cosmet Dermatol 6(2):108–112

    PubMed  Article  Google Scholar 

  12. 12.

    Saraf S, Pathak AK, Dixit VK (1991) Hair growth promoting activity of Tridax procumbens. Fitoterapia 62:495–498

    Google Scholar 

  13. 13.

    Takahashi T, Kamiya T, Yokoo Y (1998) Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Derm Venereol (Stockh) 78:428–432

    Article  CAS  Google Scholar 

  14. 14.

    Tanaka S, Saito M, Tabata M (1980) Bioassay of crude drugs for hair growth promoting activity in mice by a new simple method. Planta Med Suppl 1:84–90

    Google Scholar 

  15. 15.

    The Wealth of India (1992) vol. C, National Institute of Scientific Communication and Research, New Delhi: 612

  16. 16.

    Uno H (1991) Quantitative models for the study of hair growth in vivo. In: Stenn KS, Messenger AG, Baden HP (eds) Molecular and structural biology of hairs, vol. 642 edn. NY Acad Sci, New York, pp 107–124

    Google Scholar 

  17. 17.

    Yoo HG, Kim JS, Lee SR, Pyo HK, Moon HI, Lee JH, Kwon OS, Chung JH, Kim KH, Eun HC, Cho KH (2006) Perifollicular fibrosis: pathogenetic role in androgenetic alopecia. Biol Pharm Bull 29(6):1246–1250

    PubMed  Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to V. K. Dixit.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Roy, R.K., Thakur, M. & Dixit, V.K. Hair growth promoting activity of Eclipta alba in male albino rats. Arch Dermatol Res 300, 357–364 (2008). https://doi.org/10.1007/s00403-008-0860-3

Download citation

Keywords

  • Alopecia
  • Hair growth
  • Eclipta alba
  • Bhringraj