Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair


The appearance of hair plays an important role in people’s overall physical appearance and self-perception. Silicon (Si) has been suggested to have a role in the formation of connective tissue and is present at 1–10 ppm in hair. Choline-stabilized orthosilicic acid (“ch-OSA”) is a bioavailable form of silicon which was found to improve skin microrelief and skin mechanical properties in women with photoaged skin. The effect of ch-OSA on hair was investigated in a randomized, double blind, placebo-controlled study. Forty-eight women with fine hair were given 10 mg Si/day in the form of ch-OSA beadlets (n = 24) or a placebo (n = 24), orally for 9 months. Hair morphology and tensile properties were evaluated before and after treatment. Urinary silicon concentration increased significantly in the ch-OSA supplemented group but not in the placebo group. The elastic gradient decreased in both groups but the change was significantly smaller in the ch-OSA group (−4.52%) compared to placebo group (−11.9%). Break load changed significantly in the placebo group (−10.8%) but not in the ch-OSA supplemented group (−2.20%). Break stress and elastic modulus decreased in both groups but the change was smaller in the ch-OSA group. The cross sectional area increased significantly after 9 months compared to baseline in ch-OSA supplemented subjects but not in the placebo group. The change in urinary silicon excretion was significantly correlated with the change in cross sectional area. Oral intake of ch-OSA had a positive effect on tensile strength including elasticity and break load and resulted in thicker hair.

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ch-OSA was developed by Dirk Vanden Berghe for Bio Minerals n.v. This study was supported by a grant of Bio Minerals n.v. The Institute Dr. Schrader (Holzminden, Germany) was contracted as an independent research organization for the recruitment of volunteers and for the analysis of hair parameters.

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Correspondence to M. Calomme.

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Wickett, R.R., Kossmann, E., Barel, A. et al. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. Arch Dermatol Res 299, 499–505 (2007). https://doi.org/10.1007/s00403-007-0796-z

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  • Hair
  • Tensile strength
  • Choline-stabilized orthosilicic acid
  • Elasticity
  • Break load