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Expression of androgen and estrogen receptors in human scalp mesenchymal cells in vitro

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Abstract

The expression levels of sex hormone receptors were identified to be different in human mesenchymal cells [dermal papilla cell (DPC), dermal sheath cell (DSC), dermal fibroblast and (DF)] from occipital scalps. Transcriptional and translational activities of androgen receptor (AR) and estrogen receptor β (ERβ) were most intensely expressed in DPC, followed by DSC and DF. On the contrary, estrogen receptor α (ERα) was shown with the strongest positivity in DSC, succeeded by DPC and DF subsequently. Immunocytochemical staining showed the similar expression to previous patterns. Our results suggest that the expression levels of ER subtypes and AR may be important for the regulation of follicular mesenchymal cells in human scalp. Further studies of the interactions of hormones and receptors in human hair follicles are required to promote our understanding of the effects of sex hormones on hair biology.

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Acknowledgments

This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (# 03-PJ1-PG1-CH13-0001) and by a research agreement with AmorePacific Corporation, Korea.

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Authors and Affiliations

  1. Department of Dermatology, Seoul National University College of Medicine, Yongon-Dong 28, Chongno-Gu, 110-744, Seoul, South Korea

    Hyeon Gyeong Yoo, Chong Hyun Won, Se Rah Lee, Oh Sang Kwon, Kyu Han Kim, Hee Chul Eun & Kwang Hyun Cho

  2. Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, 110-744, Seoul, South Korea

    Hyeon Gyeong Yoo, Chong Hyun Won, Se Rah Lee, Oh Sang Kwon, Kyu Han Kim, Hee Chul Eun & Kwang Hyun Cho

  3. Institute of Dermatological Science, Seoul National University, 110-744, Seoul, South Korea

    Hyeon Gyeong Yoo, Chong Hyun Won, Se Rah Lee, Oh Sang Kwon, Kyu Han Kim, Hee Chul Eun & Kwang Hyun Cho

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  1. Hyeon Gyeong Yoo
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  2. Chong Hyun Won
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  3. Se Rah Lee
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  4. Oh Sang Kwon
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Correspondence to Kwang Hyun Cho.

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Yoo, H.G., Won, C.H., Lee, S.R. et al. Expression of androgen and estrogen receptors in human scalp mesenchymal cells in vitro. Arch Dermatol Res 298, 505–509 (2007). https://doi.org/10.1007/s00403-006-0721-x

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  • DOI: https://doi.org/10.1007/s00403-006-0721-x

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