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Serum anti-Fcγ receptor autoantibodies in patients with alopecia areata

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Abstract

Although anti-Fcγ receptor antibodies (Abs) are detected in various autoimmune diseases, there have been no studies about the anti-Fcγ receptor Abs in alopecia areata (AA). To detect the anti-Fcγ receptor Abs in patients with AA and their clinical correlations, Serum samples from 72 patients with AA and 23 normal controls were examined by enzyme-linked immunosorbent assay assessing anti-Fcγ receptor Ab levels. Anti-Fcγ receptor I Abs were significantly frequently detected in patients with AA compared with normal controls. Furthermore, the detection of anti-Fcγ receptor I Abs significantly inversely correlated with the disease duration. These results suggest that anti-Fcγ receptor I Ab and Fcγ receptor I play an important role in the regulation of AA, are useful for a marker of the disease prognosis and are worth intense research for the reasonable and specific therapy of AA.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Yoshihiro Kuwano, Rei Watanabe, Nobuko Asashima, Hiroko Nakashima, Hiroki Ohno, Shoichiro Yano, Norihito Yazawa & Kunihiko Tamaki

  2. Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan

    Yoshihiro Kuwano & Hitoshi Okochi

  3. Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan

    Manabu Fujimoto

Authors
  1. Yoshihiro Kuwano
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  2. Manabu Fujimoto
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  3. Rei Watanabe
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  4. Nobuko Asashima
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  5. Hiroko Nakashima
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  6. Hiroki Ohno
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  7. Shoichiro Yano
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  8. Norihito Yazawa
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  9. Hitoshi Okochi
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  10. Kunihiko Tamaki
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Corresponding author

Correspondence to Manabu Fujimoto.

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Kuwano, Y., Fujimoto, M., Watanabe, R. et al. Serum anti-Fcγ receptor autoantibodies in patients with alopecia areata. Arch Dermatol Res 298, 493–498 (2007). https://doi.org/10.1007/s00403-006-0717-6

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  • DOI: https://doi.org/10.1007/s00403-006-0717-6

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