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Quality of life of patients with keloid and hypertrophic scarring

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Abstract

Keloid and hypertrophic scarring represent chronic disfiguring dermatoses with a high resistance to therapy. The aim of our study was to assess for the first time the quality of life of patients with hypertrophic scars and keloids, because they suffer from quality of life impairment as much as patients with other chronic skin diseases. An item-pool was created modifying and supplementing the items of the Questionnaire on Experience with Skin Complaints. This questionnaire was distributed to 100 outpatients with keloids and hypertrophic scars. A factor analysis was used to identify the underlying dimensions. Two scales (psychological and physical impairment) of the questionnaire with nine and five items, respectively, were established. Test–retest reliability of the questionnaire was excellent (corr>0.9). Good validity was suggested by the correlation of physical impairment with pain (P≤0.001), pruritus (P<0.001), and the amount of restriction of mobility (P<0.001). The psychological scale was associated with pain and restriction of mobility, although the correlations were lower. This study demonstrates for the first time an impairment of quality of life in a large group of patients with keloid and hypertrophic scarring.

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References

  1. Atiyeh BS, Costagliola M, Hayek SN (2005) Keloid or hypertrophic scar. The controversy review of the literature. Ann Plast Surg 54:676–680

    Article  PubMed  CAS  Google Scholar 

  2. Bayat A, Bock O, Mrowietz U, Ollier WE, Ferguson MW (2002) Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms. Br J Plast Surg 55:283–286

    Article  PubMed  CAS  Google Scholar 

  3. Bayat A, Bock O, Mrowietz U, Ollier WE, Ferguson MW (2003) Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels. Plast Reconstr Surg 111:535–543

    Article  PubMed  Google Scholar 

  4. Bayat A, McGrouther DA, Ferguson MW (2003) Skin scarring. BMJ 326:88–92

    Article  PubMed  CAS  Google Scholar 

  5. Bayat A, Arscott G, Ollier WE, McGrouther DA, Ferguson MW (2005) Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg 58:28–37

    Article  PubMed  CAS  Google Scholar 

  6. Bayat A, Walter JM, Bock O, Mrowietz U, Ollier WE, Ferguson MW (2005) Genetic susceptibility to keloid disease: mutation screening of the TGFbeta(3) gene. Br J Plast Surg 58:28–37

    Article  PubMed  CAS  Google Scholar 

  7. Boutli-Kasapidou F, Tsakiri A, Anagnostou E, Mourellou O (2005) Hypertrophic and keloidal scars: an approach to polytherapy. Int J Dermatol 44:324–327

    Article  PubMed  Google Scholar 

  8. Cheng S, Chan A, Fong S, Lam M, Leung A, Lee P, Tsang J, Wong J, Wu A (1996) Outcome studies for burn patients in Hong Kong: patients’ satisfaction. Burns 22:623–626

    Article  PubMed  CAS  Google Scholar 

  9. Cohen IK, Peacock EE Jr (1990) Keloids and hypertrophic scars. Plast Surg 1:732–746

    Google Scholar 

  10. English RS, Shenefelt PD (1999) Keloids and hypertrophic scars. Dermatol Surg 25:631–638

    Article  PubMed  CAS  Google Scholar 

  11. Finlay AY, Coles EC (1995) The effect of severe psoriasis on the quality of life of 369 patients. Br J Dermatol 132:236–244

    PubMed  CAS  Google Scholar 

  12. Ginsburg IH, Link BG (1989) Feelings of stigmatization in patients with psoriasis. J Am Acad Dermatol 20:53–63

    Article  PubMed  CAS  Google Scholar 

  13. Ginsburg IH, Link BG (1993) Psychosocial consequences of rejection and stigma feelings in psoriasis patients. Int J Dermatol 32:587–591

    Article  PubMed  CAS  Google Scholar 

  14. Goffman E (1968) Stigma. Notes on the management of spoiled identity. Penguin, London

    Google Scholar 

  15. Kent G, Al’Abadie M (1996) Psychologic effects of vitiligo: a critical incident analysis. J Am Acad Dermatol 35:895–898

    Article  PubMed  CAS  Google Scholar 

  16. Kirby B, Richards HL, Woo P, Hindle E, Main CJ, Griffiths CE (2001) Physical and psychologic measures are necessary to assess overall psoriasis severity. J Am Acad Dermatol 45:72–76

    Article  PubMed  CAS  Google Scholar 

  17. Koo J, Kozma C, Reinke K (2002) The development of a disease-specific questionnaire to assess quality of life for psoriasis patients: an analysis of reliability, validity, and responsiveness of the psoriasis quality of life questionnaire. Dermatol Psychosom 3:171–179

    Article  Google Scholar 

  18. Lane JE, Waller JL, Davis LS (2005) Relationship between age of ear piercing and keloid formation. Pediatrics 115:1312–1314

    Article  PubMed  Google Scholar 

  19. Lee SS, Yosipovitch G, Chan YH, Goh CL (2004) Pruritus, pain, and small nerve fiber function in keloids: a controlled study. J Am Acad Dermatol 51:1002–1006

    Article  PubMed  Google Scholar 

  20. Lin LI (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45:255–268

    Article  PubMed  CAS  Google Scholar 

  21. Marneros AG, Norris JE, Olsen BR, Reichenberger E (2001) Clinical genetics of familial keloids. Arch Dermatol 137:1429–1434

    PubMed  CAS  Google Scholar 

  22. Mustoe TA (2004) Scars and keloids. BMJ 328:1329–1330

    Article  PubMed  Google Scholar 

  23. Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, Stella M, Teot L, Wood FM, Ziegler UE (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110:560–571

    Article  PubMed  Google Scholar 

  24. Rapp SR, Feldman SR, Exum ML, Fleischer AB Jr., Reboussin DM (1999) Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol 41:401–407

    Article  PubMed  CAS  Google Scholar 

  25. Schmid-Ott G, Jäger B, Kuensebeck HW (1998) Psychosocial influences on the illness experience of psoriasis patients. A study with the “Questionnaire on Experinece with Skin Complaints (QES)”. Z Klin Psychol Psychiatr Psychther 46:330–343

    Google Scholar 

  26. Schmid-Ott G, Kuensebeck HW, Jaeger B, Werfel T, Frahm K, Ruitman J, Kapp A, Lamprecht F (1999) Validity study for the stigmatization experience in atopic dermatitis and psoriatic patients. Acta Derm Venereol 79:443–447

    Article  PubMed  CAS  Google Scholar 

  27. Shaffer JJ, Taylor SC, Cook-Bolden F (2002) Keloidal scars: a review with a critical look at therapeutic options. J Am Acad Dermatol 46:S63–S97

    Article  PubMed  Google Scholar 

  28. Sheffield CG III, Irons GB, Mucha P Jr., Malec JF, Ilstrup DM, Stonnington HH (1988) Physical and psychological outcome after burns. J Burn Care Rehabil 9:172–177

    Article  PubMed  Google Scholar 

  29. Sherris DA, Larrabee WF Jr., Murakami CS (1995) Management of scar contractures, hypertrophic scars, and keloids. Otolaryngol Clin North Am 28:1057–1068

    PubMed  CAS  Google Scholar 

  30. Tuan TL, Nichter LS (1998) The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 4:19–24

    Article  PubMed  CAS  Google Scholar 

  31. Vardy D, Besser A, Amir M, Gesthalter B, Biton A, Buskila D (2002) Experiences of stigmatization play a role in mediating the impact of disease severity on quality of life in psoriasis patients. Br J Dermatol 147:736–742

    Article  PubMed  CAS  Google Scholar 

  32. Vensel E, Hilley T, Trent J, Taylor JR, Kirsner RS, Kerdel FA, Taylor JR, Schwartzberg JB (2000) Sustained improvement of the quality of life of patients with psoriasis after hospitalization. J Am Acad Dermatol 43:858–860

    Article  PubMed  CAS  Google Scholar 

  33. Wahl A, Loge JH, Wiklund I, Hanestad BR (2000) The burden of psoriasis:a study concerning health-related quality of life among Norwegian adult patients with psoriasis compared with general population norms. J Am Acad Dermatol 43:803–808

    Article  PubMed  CAS  Google Scholar 

  34. Zeitlin RE (1997) Long-term psychosocial sequelae of paediatric burns. Burns 23:467–472

    Article  PubMed  CAS  Google Scholar 

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Acknowledgement

This work was supported by an unrestricted educational grant from Mölnlycke Healthcare, Sweden.

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Correspondence to Oliver Bock.

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Bock, O., Schmid-Ott, G., Malewski, P. et al. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res 297, 433–438 (2006). https://doi.org/10.1007/s00403-006-0651-7

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  • DOI: https://doi.org/10.1007/s00403-006-0651-7

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