Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin

Abstract

Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid (“ch-OSA”) is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, “none=0, severe=3”) brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: −16%; Rm: −19%; Rz: −8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.

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Acknowledgements

The authors thank Dr. André Moreels and the technical staff of The Medical Centre, Vrije Universiteit Brussel, for blood sampling of the study subjects. ch-OSA was developed by Dirk Vanden Berghe for Bio Minerals n.v. This study was supported by a grant of Bio Minerals n.v.

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Correspondence to M. Calomme.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00403-006-0650-8

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Barel, A., Calomme, M., Timchenko, A. et al. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol Res 297, 147–153 (2005). https://doi.org/10.1007/s00403-005-0584-6

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Keywords

  • Photodamaged skin
  • Silicon
  • Orthosilicic acid
  • Nails
  • Hair