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Modulation of endothelial dysfunction and apoptosis: UVA1-mediated skin improvement in systemic sclerosis

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Abstract

UVA1-mediated effects regarding vascular dysregulation as a primary pathogenetic factor of systemic sclerosis skin lesions have so far not been investigated. Pre- and posttherapy skin biopsies of four patients were evaluated immunohistochemically for angiostatic, angiogenic and angioapoptotic features. Immunohistochemistry revealed a partial pretherapy loss of endothelial CD31 and CD34 expression accompanied by a posttherapy increase of CD34+ cells. Simultaneously, VEGF and M30 CytoDEATH immunolabeling demonstrated UVA1-induced neovascularization and decreased endothelial apoptosis. Our results suggest that UVA1 irradiation exerts its positive effects by a modulation of endothelial regulation/transformation beside the proposed induction of T cell apoptosis and collagenases.

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Authors and Affiliations

  1. Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany

    Frank Breuckmann, Markus Stuecker, Peter Altmeyer & Alexander Kreuter

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  1. Frank Breuckmann
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  2. Markus Stuecker
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  3. Peter Altmeyer
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  4. Alexander Kreuter
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Correspondence to Frank Breuckmann.

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Breuckmann, F., Stuecker, M., Altmeyer, P. et al. Modulation of endothelial dysfunction and apoptosis: UVA1-mediated skin improvement in systemic sclerosis. Arch Dermatol Res 296, 235–239 (2004). https://doi.org/10.1007/s00403-004-0513-0

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  • DOI: https://doi.org/10.1007/s00403-004-0513-0

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