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Inhibition of melanoma metastases by fenofibrate

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Abstract

The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) α, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR α in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.

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Acknowledgements

This work was partially supported by the Polish State Committee for Scientific Research in year 2002 (grant 3 P05A 053 23 to M.G.) and the Jagiellonian University (grants N-25/CRBW-22/2001, N-25/CRBW-VII-6/2002 to P.M.P.). The authors would also like to thank Prof. Stanislaw Lukiewicz and Dr. Krzysztof Reiss for their helpful advice and inspiring comments and Thu Ho for language correction. The secretarial assistance of Ms. Christine Crawford is also acknowledged.

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Authors and Affiliations

  1. Faculty of Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Krakow, Poland

    Maja Grabacka, Przemyslaw M. Plonka, Stanislawa Pajak & Krystyna Urbanska

  2. Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Bio-Life Sciences Building, 1900 North 12th Street, Philadelphia, PA 19122, USA

    Maja Grabacka

  3. Institute of Biochemistry, Collegium Medicum, Jagiellonian University, ul. Kopernika 7, 31-034, Krakow, Poland

    Wojciech Placha & Piotr Laidler

  4. Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, 930 Madison Ave, Memphis, TN 38163, USA

    Andrzej Slominski

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Correspondence to Maja Grabacka.

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Grabacka, M., Placha, W., Plonka, P.M. et al. Inhibition of melanoma metastases by fenofibrate. Arch Dermatol Res 296, 54–58 (2004). https://doi.org/10.1007/s00403-004-0479-y

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