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Growth medium-dependent ERK1/2 and AP-1 activity in cultured normal human keratinocytes modulates 1α,25-dihydroxyvitamin D3-induced differentiation

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References

  • Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW (1988) Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA 85:3294–3298

    CAS  PubMed  Google Scholar 

  • Bikle CD, Ng D, Tu C-L, Oda Y, Xie Z (2001) Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 177:161–171

    Google Scholar 

  • Bollag WB, Bollag R (2001) 1,25-Dihydroxyvitamin D3, phospholipase D and protein kinase C in keratinocyte differentiation. Mol Cell Endocrinol 177:173–182

    Google Scholar 

  • Casatorres J, Navarro JM, Blessing M, Jorcano JL (1994) Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element. J Biol Chem 269:20489–20496

    CAS  PubMed  Google Scholar 

  • Clarke N, Arenzana N, Hai T, Minden A, Prywes R (1998) Epidermal growth factor induction of the c-jun promotor by a Rac pathway. Mol Cell Biol 18:1065–1073

    CAS  PubMed  Google Scholar 

  • Cobb MH, Goldsmith EJ (1995) How MAP kinases are regulated. J Biol Chem 270:14843–14846

    CAS  PubMed  Google Scholar 

  • Geilen CC, Wieprecht M, Orfanos CE (1996) The mitogen-activated protein kinase system (MAP kinase cascade): its role in skin signal transduction. A review. J Dermatol Sci 12:255–262

    Article  CAS  PubMed  Google Scholar 

  • Gniadecki R (1996) Stimulation versus inhibition of keratinocyte growth by 1,25-dihydroxyvitamin D3: dependence on cell culture conditions. J Invest Dermatol 106:510–516

    Google Scholar 

  • Gupta P, Prywes R (2002) ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor induced c-jun expression. J Biol Chem 277:50550–50556

    Article  CAS  PubMed  Google Scholar 

  • Imai Y, Pike JW, Koeffler HP (1995) Potent vitamin D3 analogs: their abilities to inhance transactivation and to bind to the vitamin D3 response element. Leuk Res 19:147–158

    Article  CAS  PubMed  Google Scholar 

  • Johansen C, Iversen L, Ryborg A, Kragballe K (2000) 1α,25-Dihydroxyvitamin D3 induced differentiation of cultured human keratinocytes is accompanied by a PKC-independent regulation of AP-1 DNA binding activity. J Invest Dermatol 114:1174–1179

    Article  CAS  PubMed  Google Scholar 

  • Johansen C, Kragballe K, Henningsen J, Westergaard M, Kristiansen K, Iversen L (2003) 1α,25-Dihydroxyvitamin D3 stimulates AP-1 DNA binding activity by a PI3-kinase/Ras/MEK/ERK1/2 and JNK1 dependent increase in c-Fos, Fra1 and c-Jun expression in human keratinocytes. J Invest Dermatol 120:561–570

    CAS  PubMed  Google Scholar 

  • Kim HJ, Abdelkader N, Katz M, McLane JA (1992) 1,25-Dihydroxy-vitamin-D3 enhances antiproliferative effects and transcription of TGF-b1 in human keratinocytes in culture. J Cell Physiol 151:579–587

    CAS  PubMed  Google Scholar 

  • Laird AD, Taylor SJ, Oberst M, Shalloway D (1995) Raf-1 is activated during mitosis. J Biol Chem 270:26742–26745

    Article  CAS  PubMed  Google Scholar 

  • Lee W, Haslinger A, Karin M, Tjian R (1987) Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature 325:368–372

    Article  CAS  PubMed  Google Scholar 

  • Lu B, Rothnagel JA, Longley MA, Tsai SY, Roop DR (1994) Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. J Biol Chem 269:7443–7449

    CAS  PubMed  Google Scholar 

  • Matsumoto K, Hashimoto K, Nishida Y, Hashiro M, Yoshikawa K (1990) Growth-inhibitory effects of 1,25-dihydroxy vitamin D3 on normal human keratinocytes cultured in serum-free medium. Biochem Biophys Res Commun 166:916–923

    CAS  PubMed  Google Scholar 

  • Norman AW, Roth J, Orci L (1982) The vitamin D endocrine system: steroid metabolism, hormone receptors and biological response (calcium binding proteins). Endocr Rev 3:331–366

    CAS  PubMed  Google Scholar 

  • Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93–104

    CAS  PubMed  Google Scholar 

  • Quantin B, Breathnach R (1988) Epidermal growth factor stimulates transcription of the c-jun protooncogene in rat fibroblasts. Nature 334:538–539

    CAS  PubMed  Google Scholar 

  • Ryder K, Nathans D (1988) Induction of protooncogene c-jun by serum growth factors. Proc Natl Acad Sci USA 85:8464–8467

    PubMed  Google Scholar 

  • Smith EL, Walwort NC, Holick MF (1986) Effect of 1α,25-Dihydroxyvitamin D3 on the morphological and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. J Invest Dermatol 86:709–714

    CAS  PubMed  Google Scholar 

  • Su MJ, Bikle DD, Mancianti ML, Pillai S (1994) 1,25-Dihydroxy-vitamin D3 potentiates the keratinocyte response to calcium. J Biol Chem 269:14723–14729

    CAS  PubMed  Google Scholar 

  • Svendsen ML, Daneels G, Geysen J, Binderup L, Kragballe K (1997) Proliferation and differentiation of cultured human keratinocytes is modulated by 1,25(OH)2D3 and synthetic vitamin D3 analogues in a cell density-, calcium- and serum-dependent manner. Pharmacol Toxicol 80:49–56

    CAS  PubMed  Google Scholar 

  • Welter JF, Crish JF, Agarwal C, Eckert RL (1995) Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J Biol Chem 270:12614–12622

    Article  CAS  PubMed  Google Scholar 

  • Xie Z, Bikle DD (2001) Inhibition of 1,25-dihydroxyvitamin-D-induced keratinocyte differentiation by blocking the expression of phospholipase C-γ1. J Invest Dermatol 117:1250–1254

    Article  CAS  PubMed  Google Scholar 

  • Yamada K, Yamanishi K, Kakizuka A, Kibe Y, Doi H, Yasuno H (1994) Transcriptional regulation of human transglutaminase1 gene by signaling systems of protein kinase C, RAR/RXR and Jun/Fos in keratinocytes. Biochem Mol Biol Int 34:827–836

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Aarhus University Hospital, University of Aarhus, P. P. Orumsgade 11, 8000, Aarhus C, Denmark

    Claus Johansen, Knud Kragballe & Lars Iversen

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  1. Claus Johansen
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  2. Knud Kragballe
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  3. Lars Iversen
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Correspondence to Claus Johansen.

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Johansen, C., Kragballe, K. & Iversen, L. Growth medium-dependent ERK1/2 and AP-1 activity in cultured normal human keratinocytes modulates 1α,25-dihydroxyvitamin D3-induced differentiation. Arch Dermatol Res 295, 199–202 (2003). https://doi.org/10.1007/s00403-003-0409-4

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  • DOI: https://doi.org/10.1007/s00403-003-0409-4

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