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The use of preoperative continuous positive airway pressure in patients with obstructive sleep apnea following total knee arthroplasty: a propensity score matched analysis

  • Knee Arthroplasty
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Introduction

Patients with sleep apnea, affecting up to 1 in 4 older men in the United States, may be at increased risk of postoperative complications after total knee arthroplasty (TKA), including increased thromboembolic and cerebrovascular events, as well as respiratory, cardiac, and digestive complications. However, the extent to which the use of CPAP in patients with sleep apnea has been studied in TKA is limited.

Methods

A national, all-payer database was queried to identify all patients who underwent a primary TKA between 2010 and 2021. Patients who had any history of sleep apnea were identified and then stratified based on the use of CPAP. A propensity score match analysis was conducted to limit the influence of confounders. Medical complications, such as cardiac arrest, stroke, pulmonary embolism, transfusion, venous thromboembolism, and wound complications, were collected at 90-days, 1-year, and 2-years.

Results

The bivariate analysis showed inferior outcomes for sleep apnea with CPAP use compared to sleep apnea with no CPAP use, in terms of length of stay (5.9 vs. 5.2, p < 0.001), PJI (1.31% vs. 1.14%, p < 0.001), stroke (0.97% vs. 0.82%, p < 0.001), VTE (1.04% vs. 0.82, p < 0.001), and all other complications at 90-days (p < 0.001) except cardiac arrest (0.14% vs. 0.11%, p = 0.052), and aseptic revision (0.40% vs. 0.39%, p = 0.832), PJI (1.81% vs. 1.55%, p < 0.001) and aseptic revision (1.25% vs. 1.06%, p < 0.001) at 1-year, and PJI (2.07 vs. 1.77, p < 0.001) and aseptic revision (1.98 vs. 1.17, p < 0.001) at 2-years.

Conclusion

Patients with sleep apnea have increased postoperative complications after undergoing TKA in comparison to patients without sleep apnea. More severe sleep apnea, represented by CPAP usage in this study led to worse postoperative outcomes but further analysis is required signify the role of CPAP in this patient population. Patients with sleep apnea should be treated as a high-risk group.

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Authors and Affiliations

  1. LifeBridge Health, Sinai Hospital of Baltimore, Rubin Institute for Advanced Orthopedics, 2401 West Belvedere Avenue, Baltimore, MD, 21215, USA

    Jeremy A. Dubin, Sandeep S. Bains, Daniel Hameed, Zhongming Chen, James Nace & Ronald E. Delanois

  2. Department of Orthopaedic Surgery, WellSpan Health, York Hospital, York, PA, USA

    Hani A. Mayassi

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  1. Jeremy A. Dubin
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  2. Sandeep S. Bains
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Correspondence to Ronald E. Delanois.

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Declarations

Dr. Nace is a board or committee member of the Arthritis Foundation, is on the editorial or governing board of the Journal of Arthroplasty, Journal of the American Osteopathic Medicine Association, Orthopedic Knowledge Online, Journal of Knee Surgery, as well as Knee, is a paid consult of Microport, and receives research support from Microport, Stryker, as well as United.

Dr. Delanois is a board or committee member of the Baltimore City Medical Society and receives research support from Biocomposites, Inc., CyMedica Orthopedics, DePuy Synthes Product, Inc., Flexion Therapeutics, Microport Orthopedics, Inc., Orthofix, Inc., Patient-Centered Outcomes Research Institute (PCORI), Smith & Nephew, Stryker, Tissue Gene, as well as United Orthopedic Corporation.

All other authors have no conflicts of interest to disclose.

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Dubin, J.A., Bains, S.S., Hameed, D. et al. The use of preoperative continuous positive airway pressure in patients with obstructive sleep apnea following total knee arthroplasty: a propensity score matched analysis. Arch Orthop Trauma Surg (2024). https://doi.org/10.1007/s00402-024-05238-0

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