Abstract
Introduction
Our study aims to investigate the incidence rate and risk factors for subsequent revision in patients treated with UKA compared with those treated with HTO.
Methods
In this retrospective nationwide cohort study, we used data from the Korean National Health Insurance claims database from January 1, 2009 to December 31, 2017. We compared patients who had undergone UKA or HTO as the primary surgical procedure longer than two years prior. We used multivariable logistic regression models to compare risk of revision between the groups after propensity matching with inverse probability of treatment weighting (IPTW). Revision was defined as conversion to total knee arthroplasty (TKA) after primary UKA or HTO.
Results
In this study, 73,902 patients with UKA and 72,215 patients with HTO were identified after applying IPTW. The risk of revision during the entire study period was higher for patients with HTO than for patients with UKA (adjusted hazard ratio [HR] = 1.42). Kaplan–Meier 8-years survival was 96.8% in the UKA group and 95.1% in the HTO group. Patients with HTO who were at higher risk of revision had advanced age (60–69 years [HR = 2.17, 95% CI 1.76–2.67] and 70–79 years [HR = 2.89, 95% CI 1.81–4.62]), female sex (HR = 1.41, 95% CI 1.19–1.66), CHF (HR = 3.12, 95% CI 1.25–7.78), COPD (HR = 1.68, 95% CI 1.34–2.10), PVD (HR = 1.75, 95% CI 1.10–2.78), and CVA or TIA (HR = 1.87, 95% CI 1.13–3.08) compared with those with UKA.
Conclusion
Risk of revision was higher for patients with HTO than for patients with UKA. Risk factors for subsequent revision in patients with HTO were advanced age (60–69, 70–79), female sex, and comorbidities such as CHF, COPD, PVD, CVA, or TIA. However, orthopedic surgeons should also consider that TKA conversion from UKA has higher risk of revision than TKA conversion from HTO before choosing between UKA and HTO.
Similar content being viewed by others
References
Stoddart JC, Dandridge O, Garner A, Cobb J, van Arkel RJ (2021) The compartmental distribution of knee osteoarthritis—a systematic review and meta-analysis. Osteoarthritis Cartilage 29(4):445–455. https://doi.org/10.1016/j.joca.2020.10.011
Park S-H, Jung K-H, Chang S-W, Jang S-M, Park K-B (2020) Trends in knee surgery research in the official journal of the Korean Knee Society during the period 1999–2018: a bibliometric review. Knee Surge Relat Res 32(1):28. https://doi.org/10.1186/s43019-020-00046-3
Matsushita T, Watanabe S, Arak D et al (2021) Differences in preoperative planning for high-tibial osteotomy between the standing and supine positions. Knee Surg Relat Res 33(1):8. https://doi.org/10.1186/s43019-021-00090-7
Sabzevari S, Ebrahimpour A, Roudi MK, Kachooei AR (2016) High tibial osteotomy: a systematic review and current concept. Arch Bone Jt Surg 4(3):204–212
van Wulfften-Palthe AFY, Clement ND, Temmerman OP, Burger BJ (2018) Survival and functional outcome of high tibial osteotomy for medial knee osteoarthritis: a 10–20-year cohort study. Eur J Orthop Surg Traumatol 28(7):1381–1389. https://doi.org/10.1007/s00590-018-2199-6
Jin C, Song E-K, Santoso A, ShaligramIngale P, Choi I-S, Seon J-K (2020) Survival and risk factor analysis of medial open wedge high tibial osteotomy for unicompartment knee osteoarthritis. J Arthrosc Relat Surg 36(2):535–543. https://doi.org/10.1016/j.arthro.2019.08.040
Murray DW, Parkinson RW (2018) Usage of unicompartmental knee arthroplasty. Bone Jt J 100(4):432–435. https://doi.org/10.1302/0301-620X.100B4.BJJ-2017-0716.R1
Santoso MB, Lidong Wu (2017) Unicompartmental knee arthroplasty, is it superior to high tibial osteotomy in treating unicompartmental osteoarthritis? A meta-analysis and systemic review. J Orthop Surg Res 12(1):50. https://doi.org/10.1186/s13018-017-0552-9
Kim TK, Mittal A, Meshram P, Kim WH, Choi SM (2021) Evidence-based surgical technique for medial unicompartmental knee arthroplasty. Knee Surg Relat Res 33(1):2. https://doi.org/10.1186/s43019-020-00084-x
Spahn G, Hofmann GO, Victor L, von Engelhardt M, Li HN, Klinger HM (2013) The impact of a high tibial valgus osteotomy and unicondylar medial arthroplasty on the treatment for knee osteoarthritis: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 21(1):96–112. https://doi.org/10.1007/s00167-011-1751-2
Schraknepper J, Dimitriou D, Helmy N, Hasler J, Radzanowski S, Flury A (2020) Influence of patient selection, component positioning and surgeon’s caseload on the outcome of unicompartmental knee arthroplasty. Arch Orthop Trauma Surg 140(6):807–813. https://doi.org/10.1007/s00402-020-03413-7
Cao ZW, Mai XJ, Wang J, Feng EH, Huang YM (2018) Unicompartmental knee arthroplasty vs high tibial osteotomy for knee osteoarthritis: a systematic review and meta-analysis. J Arthroplasty 33(3):952–959. https://doi.org/10.1016/j.arth.2017.10.025
Jin QH, Lee W-G, Song E-K, Jin C, Se J-K (2021) Comparison of long-term survival analysis between open-wedge high tibial osteotomy and unicompartmental knee arthroplasty. J Arthroplasty 36(5):1562–1567. https://doi.org/10.1016/j.arth.2020.11.008
Bouguennec N, Mergenthaler G, Gicquel T et al (2020) Medium-term survival and clinical and radiological results in high tibial osteotomy: Factors for failure and comparison with unicompartmental arthroplasty. Orthop Traumatol Surg Res 106(8S):S223-230. https://doi.org/10.1016/j.otsr.2020.08.002
Han S-B, Kyung H-S, Seo I-W, Shin Y-S (2017) Better clinical outcomes after unicompartmental knee arthroplasty when comparing with high tibial osteotomy. Medicince 96(50):e9268. https://doi.org/10.1097/MD.0000000000009268
Kwon S (2009) Thirty years of national health insurance in South Korea: lessons for achieving universal health care coverage. Health Policy Plan 24(1):63–71. https://doi.org/10.1093/heapol/czn037
Lee S, Hwang J-I, Kim Y, Yoon PW, Ahn J, Yoo JJ (2016) Venous thromboembolism following hip and knee replacement arthroplasty in Korea: a nationwide study based on claims registry. J Korean Med Sci 31(1):80–88. https://doi.org/10.3346/jkms.2016.31.1.80
Soledad Cepeda M, Boston R, Farrar JT, Strom BL (2003) Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confounders. Am J Epidemiol 158(3):280–287. https://doi.org/10.1093/aje/kwg115
Austin PC (2011) An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivar Behav Res 46(3):399–424. https://doi.org/10.1080/00273171.2011.568786
Austin PC (2009) Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med 28(25):3083–3107. https://doi.org/10.1002/sim.3697
Pannell WC, Heidari KS, Mayer EN et al (2019) High tibial osteotomy survivorship: a population-based study. Orthop J Sports Med 7(12):2325967119890693. https://doi.org/10.1177/2325967119890693
Trieb K, Grohs J, Hanslik-Schnabel B, Stulnig T, Panotopoulos J, Wanivenhaus A (2006) Age predicts outcome of high-tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 14(2):149–152. https://doi.org/10.1007/s00167-005-0638-5
Gstöttner M, Pedross F, Liebensteiner M, Bach C (2008) Long-term outcome after high tibial osteotomy. Arch Orthop Trauma Surg 128(1):111–115. https://doi.org/10.1007/s00402-007-0438-0
Ryu SM, Park JW, Na HD, Shon OJ (2018) High tibial osteotomy versus unicompartmental knee arthroplasty for medial compartment arthrosis with kissing lesions in relatively young patients. Knee Surg Relat Res 30(1):17–22. https://doi.org/10.5792/ksrr.17.006
W-Dahl A, Robertsson O, Lidgren L, Miller L, Davidson D, Graves S (2010) Unicompartmental knee arthroplasty in patients aged less than 65. Acta Orthop 81(1):90–94. https://doi.org/10.3109/17453671003587150
Keenan OJF, Clement ND, Nutton R, Keating JF (2019) Older age and female gender are independent predictors of early conversion to total knee arthroplasty after high tibial osteotomy. Knee 26(1):207–212. https://doi.org/10.1016/j.knee.2018.11.008
van Raaij TM, Reijman M, Brouwer RW, Jakma TS, Verhaar JAN (2008) Survival of closing-wedge high tibial osteotomy: good outcome in men with low-grade osteoarthritis after 10–16 years. Acta Orthop 79(2):230–234. https://doi.org/10.1080/17453670710015021
Lustig S, Barba N, Magnussen RA, Servien E, Demey G, Neyret P (2012) The effect of gender on outcome of unicompartmental knee arthroplasty. Knee 19(3):176–179. https://doi.org/10.1016/j.knee.2011.03.001
Matharu G, Robb C, Baloch K, Pynsent P (2012) The Oxford medial unicompartmental knee replacement: survival and the affect of age and gender. Knee 19(6):913–917. https://doi.org/10.1016/j.knee.2012.03.004
Florea VG, Mareyev VY, Achilov AA, Popovici MI, Coats AJS, Belenkov YN (1999) Central and peripheral components of chronic heart failure: determinants of exercise tolerance. Int J Cardiol 70(1):51–56. https://doi.org/10.1016/s0167-5273(99)00047-9
Sloan A, Hussain I, Maqsood M, Eremin O, El-Sheemy M (2010) The effects of smoking on fracture healing. The Surgeon 8(2):111–116. https://doi.org/10.1016/j.surge.2009.10.014
Meidinger G, Imhoff AB, Paul J, Kirchhoff C, Sauerschnig M, Hinterwimmer S (2011) May smokers and overweight patients be treated with a medial open-wedge HTO? Risk factors for non-union. Knee Surg Sports Traumatol Arthrosc 19(3):333–339. https://doi.org/10.1007/s00167-010-1335-6
Rosteius T, Rausch V, Lotzien S, Seybold D, Schildhauer TA, Geßmann J (2021) Treatment of aseptic nonunion after medial opening-wedge high tibial osteotomy. Eur J Orthop Surg Traumatol 31(4):755–762. https://doi.org/10.1007/s00590-020-02825-w
Bradford Rice J, White AG, Scarpati LM, Wan G, Nelson WW (2017) Long-term systemic corticosteroid exposure: a systematic literature review. Clin Ther 39(11):2216–2229. https://doi.org/10.1016/j.clinthera.2017.09.011
Han S-B, Song S-Y, Shim J-H, Shin Y-S (2021) Risk of a complete exchange or failure in total knee arthroplasty and unicompartmental knee arthroplasty: a nationwide population-based cohort study from South Korea. Arch Orthop Trauma Surg 141(3):477–488. https://doi.org/10.1007/s00402-020-03675-1
Dexel J, Fritzsche H, Beyer F, Harman MK, Lützner J (2017) Open-wedge high tibial osteotomy: incidence of lateral cortex fractures and influence of fixation device on osteotomy healing. Knee Surg Sports Traumatol Arthrosc 25(3):832–837. https://doi.org/10.1007/s00167-015-3730-5
Brown NM, Engh G, Fricka K (2019) Periprosthetic fracture following partial knee arthroplasty. J Knee Surg 32(10):947–952. https://doi.org/10.1055/s-0038-1672204
Pan Y, Elm JJ, Li H et al (2019) Outcomes associated with clopidogrel-aspirin use in minor stroke or transient ischemic attack: a pooled analysis of clopidogrel in high-risk patients with acute non-disabling cerebrovascular events (CHANCE) and platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trials. JAMA Neurol 76(12):1466–1473. https://doi.org/10.1001/jamaneurol.2019.2531
Syberg S, Brandao-Burch A, Patel JJ (2012) Clopidogrel (Plavix), a P2Y12 receptor antagonist, inhibits bone cell function in vitro and decreases trabecular bone in vivo. J Bone Miner Res 27(11):2373–2386. https://doi.org/10.1002/jbmr.1690
Jørgensen NR, Grove EL, Schwarz P, Vestergaard P (2012) Clopidogrel and the risk of osteoporotic fractures: a nationwide cohort study. J Intern Med 272(4):385–393. https://doi.org/10.1111/j.1365-2796.2012.02535.x
El-Galaly A, Kappel A, Nielsen PT, Jensen SL (2019) Revision risk for total knee arthroplasty converted from medial unicompartmental knee arthroplasty: comparison with primary and revision arthroplasties, based on mid-term results from the Danish knee arthroplasty registry. J Bone Jt Surg 101(22):1999–2006. https://doi.org/10.2106/JBJS.18.01468
Badawy M, Fenstad AM, Indrekvam K, Havelin LI, Furnes O (2015) The risk of revision in total knee arthroplasty is not affected by previous high tibial osteotomy. Acta Orthop 86(6):734–739. https://doi.org/10.3109/17453674.2015.1060402
Kimm H, Yun JE, Lee S-H, Jang Y, Jee SH (2012) Validity of the diagnosis of acute myocardial infarction in Korean national medical health insurance claims data: the Korean heart study (1). Korean Circ J 42(1):10–15. https://doi.org/10.4070/kcj.2012.42.1.10
Whittaker J-P, Naudie DDR, McAuley JP, McCalden RW, MacDonald SJ, Bourne RB (2010) Does bearing design influence midterm survivorship of unicompartmental arthroplasty? Clin Orthop Relat Res 468(1):73–81. https://doi.org/10.1007/s11999-009-0975-7
Zhang W, Wang J, Li H, Wang W, George DM, Huang T (2020) Fixed- versus mobile-bearing unicompartmental knee arthroplasty: a meta-analysis. Sci Rep 10(1):19075. https://doi.org/10.1038/s41598-020-76124-z
Funding
No funding was received to assist with the preparation of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There are no conflicts of interest between any of the contributors to this manuscript.
Ethical approval
Approval was obtained from the ethics committee of Veterans Health Service Medical Center. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Yoo, JD., Huh, MH. & Shin, YS. Risk of revision in UKA versus HTO: a nationwide propensity score-matched study. Arch Orthop Trauma Surg 143, 3457–3469 (2023). https://doi.org/10.1007/s00402-022-04658-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00402-022-04658-0