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Evidence of an autoregulatory mechanism of regional bone blood flow at hypotension

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Background

Blood flow in various organs is determined by an autoregulatory mechanism that guarantees constant organ perfusion over a wide range of arterial blood pressure changes. This physiological principle has been proven for the kidney, brain and intestinal tract, but so far not for bone. This study was carried out to determine whether there is an autoregulatory mechanism of bone or not.

Methods

The fluorescent microsphere reference sample method was used to determine blood flow within the bone and kidneys. Eight anesthetized female New Zealand rabbits received left ventricular injections of fluorescent microspheres over a wide range of arterial pressure levels prior to removal of kidney, femur and tibia. Blood flow values were calculated by measurement of fluorescence intensity in kidney and bone and correlated to fluorescence intensity in the peripheral blood (reference sample).

Results

Despite a reduction of mean arterial pressure from 100 to 80 mmHg bone blood flow remained constant. Further reduction of mean arterial pressure results in a linear decrease in bone blood flow.

Conclusion

The correlation between arterial pressure and organ perfusion in the bone is similar to blood flow within the kidney, indicating the presence of an autoregulated blood flow mechanism within the bone tissue.

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Acknowledgments

This work was supported by KKF 8745155 TU Munich.

Conflict of interest

There are no conflicts of interest.

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Authors and Affiliations

  1. Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany

    Stephan Vogt, Arne J. Venjakob, Klaus Stöckl, Andreas B. Imhoff & Hermann Anetzberger

  2. Department of Orthopaedics, University Rostock, Doberaner Straße 142, 18057, Rostock, Germany

    Thomas Tischer

  3. Third Medical Department, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany

    Philipp J. Jost

  4. Walter-Brendel-Centre of Experimental Medicine Munich, Ludwig-Maximilians-University of Munich, Marchionini Straße 27, 81377, Munich, Germany

    Eckart Thein

  5. Department of Orthopaedic Sports Medicine, Hessing Stiftung Augsburg, Hessing Straße 17, 86119, Augsburg, Germany

    Stephan Vogt

  6. Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany

    Arne J. Venjakob

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  1. Stephan Vogt
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  2. Arne J. Venjakob
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  3. Klaus Stöckl
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  7. Eckart Thein
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  8. Hermann Anetzberger
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Corresponding author

Correspondence to Stephan Vogt.

Additional information

S. Vogt and A.J. Venjakob equally contributed.

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Vogt, S., Venjakob, A.J., Stöckl, K. et al. Evidence of an autoregulatory mechanism of regional bone blood flow at hypotension. Arch Orthop Trauma Surg 133, 1233–1241 (2013). https://doi.org/10.1007/s00402-013-1801-y

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  • DOI: https://doi.org/10.1007/s00402-013-1801-y

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