The clinical efficacy of the vacuum-assisted closure therapy in the management of adult osteomyelitis
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Vacuum-assisted closure (VAC) therapy is a sophisticated development of a standard surgical procedure. The purpose of this study is to evaluate the clinical efficacy of managing adult osteomyelitis with VAC therapy.
Materials and methods
We included a total of 68 patients that developed osteomyelitis with Cierny–Mader types 2, 3 and 4, and required open wound management between March 2005 and February 2009. In this study, 35 of these patients were treated by VAC therapy and the other 33 by conventional wound management. The patients were well compared with type, debridement times, wounds coverage, bacteriology and recurrence.
Of the study, the patients treated by VAC therapy had a significantly reduced recurrence (1 vs. 7 wounds, P < 0.05), decreased rate of further autodermoplasty or flap surgery (17 vs. 26 wounds, P < 0.05), and increased cases of bacterial species cultures to negative (29 vs. 15 wounds, P < 0.05), debridement times and type were similar between the two groups.
VAC therapy represents a good clinical efficacy in treating osteomyelitis; it can promote the granulation tissue formation, bacterial clearance, and reduce the needs for tissue transfer and muscle flaps in patients. In addition, it could be used as an adjuvant for the eradication of osteomyelitis and improving soft-tissue management, it may be more suitable for treating osteomyelitis with soft-tissue problems.
KeywordsVacuum-assisted closure Osteomyelitis Debridement Granulation tissue
This study was supported by the Medicine Health Sciences Fund of Zhejiang (2008A095) and the Natural Science Foundation of Zhejiang (Y208034, Y2100111).
Conflict of interest
The authors had no conflicts of interest to declare in relation to this article.
- 11.Gustilo RB, Anderson JT (1976) Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: Retrospective and prospective analyses. J Bone Joint Surg (Am) 58A:453–458Google Scholar
- 15.Joseph E, Hamori CA, Bergman S et al (2000) A prospective randomized trial of vacuum-assisted closure versus standard therapy of chronic non-healing wounds. Wounds 12:60–67Google Scholar
- 17.Mader JT, Calhoun J (1994) Long bone osteomyelitis: diagnosis and management. Hosp Prac 29:71–76Google Scholar
- 28.Webb LX, Laver D, DeFranzo A (2004) Negative pressure wound therapy in the management of orthopedic wounds. Ostomy Wound Manage 50(4A Suppl):S26–S27Google Scholar