Abstract
Introduction
Animal models have been used as insight into the pathogenesis of osteonecrosis, even though most have failed to reproduce all stages of human disease, limiting progression in experimental treatment modalities. A new surgically induced animal model of femoral head osteonecrosis in sheep is presented.
Method
Osteonecrosis was achieved using an improved method of intracephalic cryogenic lesion by means of a cryoprobe and vascular ligation.
Results
Histologic findings at 6 and 12 weeks showed progression to advanced stage osteonecrosis. MRI, the gold standard in diagnosis and follow-up in human osteonecrosis showed concordant results with histology.
Conclusion
Our model can therefore be used as a preclinical femoral head osteonecrosis model in an easily accessible animal to assess biological treatments with MRI.
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Acknowledgments
Financial support is from Fundació Ferrer Investigació and Fundació Privada A. Bosch. (Beguda, Spain). The authors thank Marta Rosal, Marielle Esteves and all the personnel at the Institut de Recerca-Hospital Unversitari Vall d’Hebron involved in the project.
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The authors have no conflict of interest.
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Vélez, R., Soldado, F., Hernández, A. et al. A new preclinical femoral head osteonecrosis model in sheep. Arch Orthop Trauma Surg 131, 5–9 (2011). https://doi.org/10.1007/s00402-010-1084-5
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DOI: https://doi.org/10.1007/s00402-010-1084-5