Acta Neuropathologica

, Volume 101, Issue 3, pp 271–276 | Cite as

Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain

  • Anna-Leena Sirén
  • Friederike Knerlich
  • Wolfgang Poser
  • Christoph H. Gleiter
  • Wolfgang Brück
  • Hannelore Ehrenreich
Regular Paper
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Abstract.

Using immunohistochemistry, expression of erythropoietin (EPO), a hypoxia-inducible neuroprotective factor, and its receptor (EPOR) were investigated in human brain tissue after ischemia/hypoxia. Autopsy brains of neuropathologically normal subjects were compared to those with ischemic infarcts or hypoxic damage. In normal brain, weak EPO/EPOR immunoreactivity was mainly neuronal. In fresh infarcts, EPO immunoreactivity appeared in vascular endothelium, EPOR in microvessels and neuronal fibers. In older infarcts reactive astrocytes exhibited EPO/EPOR immunoreactivity. Acute hypoxic brain damage was associated with vascular EPO expression, older hypoxic damage with EPO/EPOR immunoreactivity in reactive astrocytes. The pronounced up-regulation of EPO/EPOR in human ischemic/hypoxic brains underlines their role as an endogenous neuroprotective system and suggests a novel therapeutic potential in cerebrovascular disease for EPO, a clinically well-characterized and safe compound.

Erythropoietin Erythropoietin receptor Human ischemia/hypoxia Immunoreactivity Brain 

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Anna-Leena Sirén
    • 1
  • Friederike Knerlich
    • 1
  • Wolfgang Poser
    • 3
  • Christoph H. Gleiter
    • 3
  • Wolfgang Brück
    • 4
  • Hannelore Ehrenreich
    • 1
  1. 1.Max-Planck-Institute for Experimental Medicine, Hermann-Rein Strasse 3, 37075 Göttingen, Germany
  2. 2.Departments of Neurology and Psychiatry, Georg-August-University, Göttingen, Germany
  3. 3.Department of Clinical Pharmacology, Georg-August-University, 37075 Göttingen, Germany
  4. 4.Department of Neuropathology, Georg-August-University, 37075 Göttingen, Germany

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