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Acta Neuropathologica

, Volume 135, Issue 5, pp 801–803 | Cite as

Fatal Aβ cerebral amyloid angiopathy 4 decades after a dural graft at the age of 2 years

  • Dominique Hervé
  • Maximilien Porché
  • Lucie Cabrejo
  • Céline Guidoux
  • Elisabeth Tournier-Lasserve
  • Gaël Nicolas
  • Homa Adle-Biassette
  • Isabelle Plu
  • Hugues Chabriat
  • Charles Duyckaerts
Correspondence

Intracerebral injection of brain homogenates containing misfolded Aβ can seed Aβ deposition in APP transgenic mice [7]. Parenchymal and vascular amyloid deposits have been observed in iatrogenic Creutzfeldt–Jakob disease (iCJD) caused by injection of cadaver-derived growth hormone (cGH) [1, 2, 5, 10]. This observation has raised the hypothesis that hormone preparations were not only contaminated with misfolded prion protein but also with Aβ aggregates able to seed amyloid formation; Aβ aggregates were, indeed, found in cGH batches produced at the time of the contamination [2]. Dural grafts, up to now associated with iCJD, have also been suspected to seed Aβ accumulation mainly in the vessel walls [3, 4, 6, 9]. Seeded Aβ aggregation, however, has not been previously associated with clinical manifestations [1]. We report here the case of a 46-year-old woman who died of repeated intracerebral hemorrhages caused by cerebral amyloid angiopathy (CAA), presumably related to contaminated...

Notes

Acknowledgements

The authors are grateful to the family of the patient that permitted the publication and helped the documentation of the clinical history. The role of the Brain Bank NeuroCEB funded by the patients’ Associations Vaincre Alzheimer, France Parkinson, Fondation ARSEP, Comprendre les Syndromes Cérébelleux, IHU A-ICM, and Fondation Plan Alzheimer is greatly acknowledged.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Dominique Hervé
    • 1
    • 2
  • Maximilien Porché
    • 1
  • Lucie Cabrejo
    • 3
    • 4
    • 5
  • Céline Guidoux
    • 3
    • 4
    • 5
  • Elisabeth Tournier-Lasserve
    • 2
    • 5
    • 6
  • Gaël Nicolas
    • 7
  • Homa Adle-Biassette
    • 5
    • 8
  • Isabelle Plu
    • 9
  • Hugues Chabriat
    • 1
    • 2
    • 5
  • Charles Duyckaerts
    • 9
    • 10
  1. 1.Service de Neurologie, Centre de référence des maladies vasculaires rares du cerveau et de l’œil (CERVCO)APHP, Hôpital LariboisièreParisFrance
  2. 2.Inserm U1161, génétique et physiopathologie des maladies cérébro-vasculairesParisFrance
  3. 3.Service de Neurologie et centre d’accueil et de traitement de l’attaque cérébralAPHP, Hôpital BichatParisFrance
  4. 4.INSERM LVTS (Laboratory for Vascular Translational Science) 1148ParisFrance
  5. 5.Université Paris 7 Diderot, Sorbonne Paris citéParisFrance
  6. 6.Laboratoire de génétique moléculaireAPHP, Hôpital LariboisièreParisFrance
  7. 7.Normandie Univ, UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized MedicineRouenFrance
  8. 8.Laboratoire d’anatomopathologieAPHP, Hôpital LariboisièreParisFrance
  9. 9.Département de Neuropathologie Raymond EscourolleGH Pitié-Salpêtrière, Faculté de médecine Sorbonne UniversitéParisFrance
  10. 10.Alzheimer Prions teamInstitut du Cerveau et de la MoelleParisFrance

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