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Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

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References

  1. Alsufayan R, Alcaide-Leon P, de Tilly LN, Mandell DM, Krings T (2017) Natural history of lesions with the MR imaging appearance of multinodular and vacuolating neuronal tumor. Neuroradiology 59:873–883

    Article  PubMed  Google Scholar 

  2. Arai Y, Totoki Y, Hosoda F et al (2014) Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. Hepatology 59:1427–1434

    Article  CAS  PubMed  Google Scholar 

  3. Brown NA, Furtado LV, Betz BL et al (2014) High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis. Blood 124:1655–1658

    Article  CAS  PubMed  Google Scholar 

  4. Cathcart SJ, Klug JR, Helvey JT, White ML, Gard AP, McComb RD (2017) Multinodular and vacuolating neuronal tumor: a rare seizure-associated entity. Am J Surg Pathol 41:1005–1010

    Article  PubMed  Google Scholar 

  5. Chakraborty R, Burke TM, Hampton OA et al (2016) Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis. Blood 128:2533–2537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chakraborty R, Hampton OA, Shen X et al (2014) Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood 124:3007–3015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Dahlman KB, Xia J, Hutchinson K et al (2012) BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. Cancer Discov 2:791–797

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Huse JT, Edgar M, Halliday J, Mikolaenko I, Lavi E, Rosenblum MK (2013) Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion. Brain Pathol 23:515–524

    Article  PubMed  Google Scholar 

  9. Huse JT, Snuderl M, Jones DT et al (2017) Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway. Acta Neuropathol 133:417–429

    Article  CAS  PubMed  Google Scholar 

  10. Kline CN, Joseph NM, Grenert JP et al (2017) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-Oncol 19:699–709

    PubMed  Google Scholar 

  11. Nunes RH, Hsu CC, da Rocha AJ et al (2017) Multinodular and vacuolating neuronal tumor of the cerebrum: a new “leave me alone” lesion with a characteristic imaging pattern. Am J Neuroradiol 38:1899–1904

    Article  CAS  PubMed  Google Scholar 

  12. Ozkaya N, Rosenblum MK, Durham BH et al (2017) The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort. Mod Pathol. https://doi.org/10.1038/modpathol.2017.160 (Epub ahead of print)

    PubMed  Google Scholar 

  13. Thom M, Liu J, Bongaarts A et al (2017) Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia? Brain Pathol. https://doi.org/10.1111/bpa.12555 (Epub ahead of print)

    Google Scholar 

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Acknowledgements

B.C.B. is supported by an NCI Outstanding Investigator Award (R35 CA220481). D.A.S. is supported by NIH Director’s Early Independence Award (DP5 OD021403) and the UCSF Physician-Scientist Scholar Program. We thank the UCSF Brain Tumor Research Center (supported by NIH SPORE Grant P50 CA097257) for assistance with phospho-ERK immunohistochemistry.

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Authors and Affiliations

  1. Department of Pathology, University of California, San Francisco, San Francisco, CA, USA

    Melike Pekmezci, Meredith Stevers, Joanna J. Phillips, Jessica Van Ziffle, Boris C. Bastian, Tarik Tihan, Arie Perry & David A. Solomon

  2. Department of Neurological Surgery, University of California, San Francisco, CA, USA

    Joanna J. Phillips & Arie Perry

  3. Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA

    Jessica Van Ziffle, Boris C. Bastian & David A. Solomon

  4. Departments of Pathology and Neuroscience, Mount Sinai Hospital, Icahn School of Medicine, New York, NY, USA

    Nadejda M. Tsankova

  5. Departments of Pathology, Neurology, and Neurosurgery, University of Colorado, Aurora, CO, USA

    Bette K. Kleinschmidt-DeMasters

  6. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Marc K. Rosenblum

Authors
  1. Melike Pekmezci
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  2. Meredith Stevers
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  4. Jessica Van Ziffle
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  5. Boris C. Bastian
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  6. Nadejda M. Tsankova
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  7. Bette K. Kleinschmidt-DeMasters
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  8. Marc K. Rosenblum
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  9. Tarik Tihan
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  10. Arie Perry
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  11. David A. Solomon
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Corresponding author

Correspondence to David A. Solomon.

Ethics declarations

This study was approved by the Committee on Human Research of the University of California, San Francisco, with a waiver of patient consent.

Conflict of interest

The authors declare that they have no competing interests related to this study.

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Pekmezci, M., Stevers, M., Phillips, J.J. et al. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol 135, 485–488 (2018). https://doi.org/10.1007/s00401-018-1820-4

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  • DOI: https://doi.org/10.1007/s00401-018-1820-4

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