Acta Neuropathologica

, Volume 135, Issue 4, pp 635–638 | Cite as

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation

  • J. Bryan Iorgulescu
  • Jessica Van Ziffle
  • Meredith Stevers
  • James P. Grenert
  • Boris C. Bastian
  • Lukas Chavez
  • Damian Stichel
  • Ivo Buchhalter
  • David Samuel
  • Theodore Nicolaides
  • Anuradha Banerjee
  • Sabine Mueller
  • Nalin Gupta
  • Tarik Tihan
  • Andrew W. Bollen
  • Paul A. Northcott
  • Marcel Kool
  • Stefan Pfister
  • Andrey Korshunov
  • Arie Perry
  • David A. Solomon
Correspondence

Notes

Acknowledgements

J.B.I. is supported by the Arthur Purdy Stout Stipend Award. B.C.B. is supported by an NCI Outstanding Investigator Award (R35 CA220481). D.A.S. is supported by NIH Director’s Early Independence Award (DP5 OD021403).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests related to this report.

Supplementary material

401_2018_1819_MOESM1_ESM.xlsx (32 kb)
Supplementary material 1 (XLSX 32 kb)
401_2018_1819_MOESM2_ESM.pdf (12 mb)
Supplementary material 2 (PDF 12338 kb)

References

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    Cavalli FMG, Remke M, Rampasek L et al (2017) Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell 31:737–754CrossRefPubMedGoogle Scholar
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    Kool M, Korshunov A, Remke M et al (2012) Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol 123:473–484CrossRefPubMedPubMedCentralGoogle Scholar
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    Morrissy AS, Cavalli FMG, Remke M et al (2017) Spatial heterogeneity in medulloblastoma. Nat Genet 49:780–788CrossRefPubMedPubMedCentralGoogle Scholar
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    Northcott PA, Buchhalter I, Morrissy AS et al (2017) The whole-genome landscape of medulloblastoma subtypes. Nature 547:311–317CrossRefPubMedGoogle Scholar
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    Northcott PA, Korshunov A, Witt H et al (2011) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 29:1408–1414CrossRefPubMedGoogle Scholar
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    Northcott PA, Shih DJ, Peacock J et al (2012) Subgroup-specific structural variation across 1000 medulloblastoma genomes. Nature 488:49–56CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Pugh TJ, Weeraratne SD, Archer TC et al (2012) Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488:106–110CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • J. Bryan Iorgulescu
    • 1
    • 15
  • Jessica Van Ziffle
    • 1
    • 2
  • Meredith Stevers
    • 1
  • James P. Grenert
    • 1
    • 2
  • Boris C. Bastian
    • 1
    • 2
  • Lukas Chavez
    • 3
    • 6
  • Damian Stichel
    • 4
    • 5
    • 6
  • Ivo Buchhalter
    • 7
    • 8
  • David Samuel
    • 9
  • Theodore Nicolaides
    • 10
    • 11
  • Anuradha Banerjee
    • 10
    • 11
  • Sabine Mueller
    • 10
    • 11
    • 12
  • Nalin Gupta
    • 11
  • Tarik Tihan
    • 1
  • Andrew W. Bollen
    • 1
  • Paul A. Northcott
    • 13
  • Marcel Kool
    • 3
    • 6
  • Stefan Pfister
    • 3
    • 6
    • 14
  • Andrey Korshunov
    • 4
    • 5
    • 6
  • Arie Perry
    • 1
    • 11
  • David A. Solomon
    • 1
    • 2
  1. 1.Department of PathologyUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Clinical Cancer Genomics LaboratoryUniversity of CaliforniaSan FranciscoUSA
  3. 3.Hopp Children′s Cancer CenterNCT Heidelberg (KiTZ)HeidelbergGermany
  4. 4.Department of NeuropathologyHeidelberg University HospitalHeidelbergGermany
  5. 5.Clinical Cooperation Unit NeuropathologyGerman Cancer Research Center (DKFZ)HeidelbergGermany
  6. 6.Division of Pediatric Neuro-oncologyGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)HeidelbergGermany
  7. 7.Division of Applied BioinformaticsGerman Cancer Research Center (DKFZ)HeidelbergGermany
  8. 8.Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB)Heidelberg UniversityHeidelbergGermany
  9. 9.Division of Pediatric Hematology/OncologyValley Children’s HospitalMaderaUSA
  10. 10.Division of Pediatric Hematology/Oncology, Department of PediatricsUniversity of CaliforniaSan FranciscoUSA
  11. 11.Department of Neurological SurgeryUniversity of CaliforniaSan FranciscoUSA
  12. 12.Department of NeurologyUniversity of CaliforniaSan FranciscoUSA
  13. 13.Department of Developmental NeurobiologySt Jude Children’s Research HospitalMemphisUSA
  14. 14.Department of Pediatric Hematology and OncologyHeidelberg University HospitalHeidelbergGermany
  15. 15.Department of PathologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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