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Regional levels of physiological α-synuclein are directly associated with Lewy body pathology

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References

  1. Brundin P, Melki R, Kopito R (2010) Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 11:301–307. https://doi.org/10.1038/nrm2873

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A et al (2014) Pathological alpha-synuclein propagates through neural networks. Acta Neuropathol Commun 2:88. https://doi.org/10.1186/s40478-014-0088-8

    Article  PubMed  PubMed Central  Google Scholar 

  3. Mittal S, Bjornevik K, Im DS, Flierl A, Dong X et al (2017) beta2-Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson’s disease. Science (New York, NY) 357:891–898. https://doi.org/10.1126/science.aaf3934

    Article  CAS  Google Scholar 

  4. Seidel K, Bouzrou M, Heidemann N, Kruger R, Schols L et al (2017) Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies. Ann Neurol 81:898–903. https://doi.org/10.1002/ana.24937

    Article  CAS  PubMed  Google Scholar 

  5. Surmeier DJ, Obeso JA, Halliday GM (2017) Selective neuronal vulnerability in Parkinson disease. Nat Rev Neurosci 18:101–113. https://doi.org/10.1038/nrn.2016.178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Taguchi K, Watanabe Y, Tsujimura A, Tanaka M (2016) Brain region-dependent differential expression of alpha-synuclein. J Comp Neurol 524:1236–1258. https://doi.org/10.1002/cne.23901

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Tissue for this study was provided by Newcastle Brain Tissue Resource, which is funded in part by a grant from the UK Medical Research Council and by Brains for Dementia Research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK. D.E. is funded by Alzheimer’s Research UK.

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Correspondence to Daniel Erskine.

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Ethical approval was granted by Newcastle University Ethics Board and the Joint Ethics Committee of Newcastle and North Tyneside Health Authority (ref: 08/H0906/136).

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Erskine, D., Patterson, L., Alexandris, A. et al. Regional levels of physiological α-synuclein are directly associated with Lewy body pathology. Acta Neuropathol 135, 153–154 (2018). https://doi.org/10.1007/s00401-017-1787-6

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  • DOI: https://doi.org/10.1007/s00401-017-1787-6

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