Acta Neuropathologica

, Volume 134, Issue 6, pp 961–963 | Cite as

Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression

  • Giselle Y. Lopez
  • Nancy Ann Oberheim Bush
  • Joanna J. Phillips
  • John-Paul Bouffard
  • Yaron A. Moshel
  • Kurt Jaeckle
  • B. K. Kleinschmidt-DeMasters
  • Marc K. Rosenblum
  • Arie Perry
  • David A. Solomon
Correspondence

Supplementary material

401_2017_1780_MOESM1_ESM.pdf (7.2 mb)
Supplementary material 1 (PDF 7343 kb)

References

  1. 1.
    Castel D, Philippe C, Calmon R et al (2015) Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol 130:815–827CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Hoffman LM, DeWire M, Ryall S et al (2016) Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol Commun 4:1CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Kline CN, Joseph NM, Grenert JP et al (2017) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-Oncology 19:699–709PubMedGoogle Scholar
  4. 4.
    Louis DN, Ohgaki H, Wiestler OD et al (2016) WHO classification of tumours of the central nervous system. IARC, LyonGoogle Scholar
  5. 5.
    Nikbakht H, Panditharatna E, Mikael LG et al (2016) Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nat Commun 7:11185CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Solomon DA, Wood MD, Tihan T et al (2016) Diffuse midline gliomas with histone H3-K27M mutation: a series of 47 cases assessing the spectrum of morphologic variation and associated genetic alterations. Brain Pathol 26:569–580CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Giselle Y. Lopez
    • 1
  • Nancy Ann Oberheim Bush
    • 2
  • Joanna J. Phillips
    • 1
    • 3
  • John-Paul Bouffard
    • 4
  • Yaron A. Moshel
    • 5
    • 6
  • Kurt Jaeckle
    • 7
  • B. K. Kleinschmidt-DeMasters
    • 8
  • Marc K. Rosenblum
    • 9
  • Arie Perry
    • 1
    • 3
  • David A. Solomon
    • 1
    • 10
  1. 1.Division of Neuropathology, Department of PathologyUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Division of Neuro-Oncology, Department of Neurological SurgeryUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of Neurological SurgeryUniversity of CaliforniaSan FranciscoUSA
  4. 4.Department of PathologyOverlook Medical CenterSummitUSA
  5. 5.Atlantic Neurosurgical SpecialistsSummitUSA
  6. 6.Department of NeurosurgeryNYU Langone Medical CenterNew YorkUSA
  7. 7.Department of NeurosciencesAtlantic Health SystemSummitUSA
  8. 8.Departments of Pathology, Neurology, and NeurosurgeryUniversity of ColoradoAuroraUSA
  9. 9.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  10. 10.Clinical Cancer Genomics Laboratory, Department of PathologyUniversity of CaliforniaSan FranciscoUSA

Personalised recommendations