This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Bastian BC, Olshen AB, LeBoit PE, Pinkel D (2003) Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol 163:1765–1770
Bastian BC, Xiong J, Frieden IJ, Williams ML, Chou P, Busam K, Pinkel D, LeBoit PE (2002) Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas. Am J Pathol 161:1163–1169
Brat DJ, Perry A, Wesseling P, Bastian BC (2016) Melanocytic tumors. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Figarella-Branger D, Perry A, Reifenberger G, von Deimling A (eds) WHO classification of tumours of the central nervous system. IARC, Lyon, pp 266–270
Grini-Mazouzi M, Thouvenot E, Sabaah M, Rigau V, Charif M (2012) Leptomeningeal melanocytosis: a fatal course of a benign tumor. Rev Neurol 168:461–463
Kinsler VA, Thomas AC, Ishida M, Bulstrode NW, Loughlin S, Hing S, Chalker J, McKenzie K, Abu-Amero S, Slater O et al (2013) Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS. J Invest Dermatol 133:2229–2236
Kusters-Vandevelde HV, Willemsen AE, Groenen PJ, Kusters B, Lammens M, Wesseling P, Djafarihamedani M, Rijntjes J, Delye H, Willemsen MA et al (2014) Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor. Acta Neuropathol Commun 2:41
Waelchli R, Aylett SE, Atherton D, Thompson DJ, Chong WK, Kinsler VA (2015) Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies magnetic resonance imaging as the best predictor of clinical outcome. Br J Dermatol 173:739–750
This work was supported by a research grant from the Koppie-Au foundation, Breda, The Netherlands.
Conflict of interest
The authors state no conflict of interest.
A. C. H. van Engen-van Grunsven and K. Rabold contributed equally to this work.
Electronic supplementary material
Below is the link to the electronic supplementary material.
About this article
Cite this article
van Engen-van Grunsven, A.C.H., Rabold, K., Küsters-Vandevelde, H.V.N. et al. Copy number variations as potential diagnostic and prognostic markers for CNS melanocytic neoplasms in neurocutaneous melanosis. Acta Neuropathol 133, 333–335 (2017). https://doi.org/10.1007/s00401-016-1654-x
- Copy Number Variation
- Cutaneous Melanoma
- Copy Number Loss
- Primary Cutaneous Melanoma