Skip to main content

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. 1.

    Betemps D, Verchere J, Brot S, Morignat E, Bousset L, Gaillard D, Lakhdar L, Melki R, Baron T (2014) Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological alpha-synuclein by enhanced ELISA. Acta Neuropathol Commun 2:29. doi:10.1186/2051-5960-2-29

    PubMed  PubMed Central  Article  Google Scholar 

  2. 2.

    Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34:521–533 (S0896627302006827 [pii])

    PubMed  CAS  Article  Google Scholar 

  3. 3.

    Luk KC, Kehm VM, Zhang B, O’Brien P, Trojanowski JQ, Lee VM (2012) Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. J Exp Med 209:975–986. doi:10.1084/jem.20112457

    PubMed  CAS  PubMed Central  Article  Google Scholar 

  4. 4.

    Mougenot AL, Nicot S, Bencsik A, Morignat E, Verchere J, Lakhdar L, Legastelois S, Baron T (2012) Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging 33:2225–2228. doi:10.1016/j.neurobiolaging.2011.06.022

    PubMed  CAS  Article  Google Scholar 

  5. 5.

    Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN et al (2015) Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci USA. doi:10.1073/pnas.1514475112

  6. 6.

    Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI (2015) Studies of lipopolysaccharide effects on the induction of alpha-synuclein pathology by exogenous fibrils in transgenic mice. Mol Neurodegener 10:32. doi:10.1186/s13024-015-0029-4

    PubMed  PubMed Central  Article  Google Scholar 

  7. 7.

    Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR et al (2014) Intramuscular injection of alpha-synuclein induces CNS alpha-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci USA 111:10732–10737. doi:10.1073/pnas.1321785111

    PubMed  CAS  PubMed Central  Article  Google Scholar 

  8. 8.

    Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI (2014) Amyloidogenic alpha-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathol 127:645–665. doi:10.1007/s00401-014-1268-0

    PubMed  CAS  Article  Google Scholar 

  9. 9.

    Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB (2013) Transmission of multiple system atrophy prions to transgenic mice. Proc Natl Acad Sci USA 110:19555–19560. doi:10.1073/pnas.1318268110

    PubMed  CAS  PubMed Central  Article  Google Scholar 

Download references

Acknowledgments

This study was supported by NINDS R01-NS089622 (BG) and R01-NS092788 (DB).

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Benoit I. Giasson or David R. Borchelt.

Ethics declarations

Conflict of interest

The author(s) declare that they have no other competing interests.

Electronic supplementary material

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sacino, A.N., Ayers, J.I., Brooks, M.M.T. et al. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathol 131, 151–154 (2016). https://doi.org/10.1007/s00401-015-1505-1

Download citation

Keywords

  • Motor Phenotype
  • Intrahippocampal Injection
  • Spinal Cord Homogenate
  • Asymptomatic Mouse
  • Accelerate Disease Onset