Skip to main content

High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. Chappe C, Padovani L, Scavarda D, Forest F, Nanni-Metellus I, Loundou A, Mercurio S, Fina F, Lena G, Colin C et al (2013) Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol 23:574–583. doi:10.1111/bpa.12048

    Article  PubMed  Google Scholar 

  2. Dasgupta T, Haas-Kogan DA (2013) The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas. Front Oncol 3:110. doi:10.3389/fonc.2013.00110

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Kim YH, Nonoguchi N, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Mariani L, Giangaspero F, Tanaka Y et al (2012) Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss. Brain Pathol 22:834–840. doi:10.1111/j.1750-3639.2012.00601.x

    Article  CAS  PubMed  Google Scholar 

  4. Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG, Bar EE (2012) BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol 71:66–72. doi:10.1097/NEN.0b013e31823f2cb0

    Article  CAS  PubMed  Google Scholar 

  5. Perilongo G, Gardiman M, Bisaglia L, Rigobello L, Calderone M, Battistella A, Burnelli R, Giangaspero F (2002) Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg 18:505–512. doi:10.1007/s00381-002-0626-8

    Article  Google Scholar 

  6. Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D, Mosier S, Lin MT, Eberhart CG, Burger PC (2012) Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 124:627–641. doi:10.1007/s00401-012-1037-x

    Article  PubMed  Google Scholar 

  7. Rossi S, Rodriguez FJ, Mota RA, Dei Tos AP, Di Paola F, Bendini M, Agostini S, Longatti P, Jenkins RB, Giannini C (2009) Primary leptomeningeal oligodendroglioma with documented progression to anaplasia and t(1;19)(q10;p10) in a child. Acta Neuropathol 118:575–577. doi:10.1007/s00401-009-0565-5

    Article  PubMed  Google Scholar 

  8. Schniederjan MJ, Alghamdi S, Castellano-Sanchez A, Mazewski C, Brahma B, Brat DJ, Brathwaite CD, Janss AJ (2013) Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry. Am J Surg Pathol 37:763–771. doi:10.1097/PAS.0b013e31827bf4cc

    Article  PubMed  Google Scholar 

  9. Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, Resnick AC (2013) Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc Natl Acad Sci USA 110:5957–5962. doi:10.1073/pnas.1219232110

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to thank Roxanne Marshall at UCSF for her excellent technical work performing FISH.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matthew J. Schniederjan.

Additional information

F. J. Rodriguez and M. J. Schniederjan contributed equally to the work.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rodriguez, F.J., Schniederjan, M.J., Nicolaides, T. et al. High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). Acta Neuropathol 129, 609–610 (2015). https://doi.org/10.1007/s00401-015-1400-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-015-1400-9

Keywords

  • Pilocytic Astrocytoma
  • BRAF V600E Mutation
  • Ganglioglioma
  • Dysembryoplastic Neuroepithelial Tumor
  • Pleomorphic Xanthoastrocytoma