Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors
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Reduced health-related quality of life (HRQoL), including impaired cognitive, social, physical, behavioural and emotional functioning, is common in children treated for medulloblastoma [1, 2, 7] and has been associated with clinical factors such as surgical resection and treatment modality [2, 5, 6]. Recent biological advances have allowed the distinction of medulloblastomas into four consensus molecular subgroups—WNT, SHH, Group 3 and Group 4—which display distinct molecular, clinical, and pathological disease characteristics [3, 4, 8, 9]. Together, these observations raise the hypothesis that HRQoL in medulloblastoma survivors may be related to their underlying tumour biology.
We have previously reported the extensive characterisation of clinical outcomes , HRQoL , and biomarker-driven prognostication schemes  for children with medulloblastoma treated on the SIOP-UKCCSG PNET3 clinical trial. Moreover, we have recently described, in this journal, the robust assignment of...
KeywordsMedulloblastoma Craniospinal Irradiation HRQoL Outcome Molecular Subgroup Total Difficulty Score
This work was conducted on behalf of the UK Children’s Cancer and Leukemia Group (CCLG), and was supported by Grants from The Brain Tumour Charity and Cancer Research UK. Medulloblastomas investigated in this study were provided as part of CCLG approved biological study BS-2007-04. This study was conducted with ethics committee approval from Newcastle/North Tyneside and Trent RECs (study reference numbers 07/Q0905/71; MREC/02/4/019). The task of identifying associations between biological subtype and quality of survival was made possible by funding from the European Union’s Seventh Framework Programme (FP7/2007-13) under the project ENCCA, grant agreement HEALTH-F2-2011-261474.
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