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TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas

Acta Neuropathologica volume 126, pages 939–941 (2013)Cite this article

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Acknowledgments

This work was supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan [No. 24659650 (H.A.)], and by the National Cancer Center Research and Development Fund [23-A-50 (K.I.)]. The authors thank Dr Sylvia Kocialkowski for critical reading of the manuscript.

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Affiliations

  1. Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Hideyuki Arita, Yoshitaka Narita, Yuko Matsushita, Yasuji Miyakita, Makoto Ohno & Soichiro Shibui

  2. Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Hirokazu Takami, Shintaro Fukushima & Koichi Ichimura

  3. Department of Neurosurgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Hirokazu Takami

  4. Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan

    Akihiko Yoshida

Authors
  1. Hideyuki Arita
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  2. Yoshitaka Narita
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  3. Hirokazu Takami
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  4. Shintaro Fukushima
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  5. Yuko Matsushita
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  6. Akihiko Yoshida
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  7. Yasuji Miyakita
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  8. Makoto Ohno
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  9. Soichiro Shibui
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  10. Koichi Ichimura
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Corresponding author

Correspondence to Koichi Ichimura.

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Arita, H., Narita, Y., Takami, H. et al. TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas. Acta Neuropathol 126, 939–941 (2013). https://doi.org/10.1007/s00401-013-1203-9

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  • DOI: https://doi.org/10.1007/s00401-013-1203-9

Keywords

  • Methylation Status
  • Methylation Level
  • Promoter Mutation
  • Oligodendroglial Tumor
  • TERT Promoter Mutation