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Which type of inflammation can be controlled by Foxp3+ Tregs?

Acta Neuropathologica volume 126, pages 523–524 (2013)Cite this article

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References

  1. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL (2002) CD4+ CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420:502–507

    PubMed  Article  CAS  Google Scholar 

  2. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235–238

    PubMed  Article  CAS  Google Scholar 

  3. Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY (2009) CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326:986–991

    PubMed  Article  CAS  Google Scholar 

  4. Chen Z, Barbi J, Bu S, Yang H-Y, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B (2013) The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3. Immunity 39:272–285

    PubMed  Article  CAS  Google Scholar 

  5. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho I-C, Khoury S, Oukka M, Kuchroo VK (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(−) effector T cells. Nat Immunol 9:1347–1355

    PubMed  Article  CAS  Google Scholar 

  6. Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ, Ahlfors H, Wilhelm C, Tolaini M, Menzel U, Garefalaki A, Potocnik AJ, Stockinger B (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12:255–263

    PubMed  Article  CAS  Google Scholar 

  7. Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A (2007) Conventional T-bet(+) Foxp3(−) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med 204:273–283

    PubMed  Article  CAS  Google Scholar 

  8. Kelchtermans H, De Klerck B, Mitera T, Van Balen M, Bullens D, Billiau A, Leclercq G, Matthys P (2005) Defective CD4+ CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthr Res Ther 7:R402–R415

    Article  CAS  Google Scholar 

  9. Kim JM, Rasmussen JP, Rudensky AY (2007) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8:191–197

    PubMed  Article  CAS  Google Scholar 

  10. Koch MA, Gas Tucker-Heard, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10:595–602

    PubMed  Article  CAS  Google Scholar 

  11. Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK (2007) Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 13:423–431

    PubMed  Article  CAS  Google Scholar 

  12. Kurschus FC, Croxford AL, Heinen AP, Wörtge S, Ielo D, Waisman A (2010) Genetic proof for the transient nature of the Th17 phenotype. Eur J Immunol 40:3336–3346

    PubMed  Article  CAS  Google Scholar 

  13. Lowther DE, Chong DL, Ascough S, Ettorre A, Ingram RJ, Boyton RJ, Altmann DM (2013) Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response. Acta Neuropathol. doi:10.1007/s00401-013-1159-9

  14. Mcgeachy MJ, Stephens LA, Anderton SM (2005) Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+ CD25+ regulatory cells within the central nervous system. J Immunol 175:3025–3032

    PubMed  CAS  Google Scholar 

  15. Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL (1993) Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5:1461–1471

    PubMed  Article  CAS  Google Scholar 

  16. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR, Muller W, Rudensky AY (2008) Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28:546–558

    PubMed  Article  CAS  Google Scholar 

  17. Zheng Y, Chaudhry A, Kas A, Deroos P, Kim JM, Chu T–T, Corcoran L, Treuting P, Klein U, Rudensky AY (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458:351–356

    PubMed  Article  CAS  Google Scholar 

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Affiliations

  1. Klinikum Rechts Der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

    Thomas Korn

  2. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

    Thomas Korn

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  1. Thomas Korn
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Correspondence to Thomas Korn.

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Korn, T. Which type of inflammation can be controlled by Foxp3+ Tregs?. Acta Neuropathol 126, 523–524 (2013). https://doi.org/10.1007/s00401-013-1178-6

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  • DOI: https://doi.org/10.1007/s00401-013-1178-6

Keywords

  • Diphtheria
  • Diphtheria Toxin
  • Treg Response
  • Pathogen Eradication
  • Peripheral Immune Tolerance