Acta Neuropathologica

, Volume 119, Issue 5, pp 523–541 | Cite as

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

  • Gunnar K. Gouras
  • Davide Tampellini
  • Reisuke H. Takahashi
  • Estibaliz Capetillo-Zarate


The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark of Alzheimer’s disease (AD) neuropathology and reduction of Aβ has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Aβ is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Aβ have been viewed as the most important pathogenic form of Aβ in AD. More recently, the intraneuronal accumulation of Aβ has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Aβ accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal β-amyloid for AD pathology, biology, diagnosis and therapy.


Amyloid Synapse Tau Head injury Endosome Dementia pugilistica 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Gunnar K. Gouras
    • 1
  • Davide Tampellini
    • 1
  • Reisuke H. Takahashi
    • 2
  • Estibaliz Capetillo-Zarate
    • 1
  1. 1.Department for Neurology and NeuroscienceWeill Cornell Medical CollegeNew YorkUSA
  2. 2.Department of PathologyTokyo Medical University HospitalTokyoJapan

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