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Ein tierexperimentelles Modell zur Verbesserung der Organkonservierung bei Lungentransplantation

An animal model to enhance organ preservation in lung transplantation

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Zeitschrift für Herz-,Thorax- und Gefäßchirurgie Aims and scope

Zusammenfassung

Der zunehmende Bedarf an Lungentransplantationen, bei gleichzeitigem Rückgang an verfügbaren Spenderorganen, macht es einerseits notwendig, weite Transportwege und damit Ischämiezeiten in Kauf zu nehmen, andererseits die Qualitätsgrenzen der Spenderorgane zu erweitern. Die Anforderungen an eine zuverlässige Konservierungsmethode sind daher hoch. Als klinischer Standard gilt nach wie vor das Spülen der Pulmonalarterie mit der Perfadex-Lösung bei 4°C. Unser Projekt hat zum Ziel, diese Konservierungsmethode mit Zusatz von CNI-1493 bzw. Compstatin zu verbessern. Die Versuche dazu werden an einem isolierten Organmodell durchgeführt.

Abstract

The increasing demand for lung transplants, which is accompanied by a decrease in the number of available donor organs, makes it necessary to take not only long transport distances and long ischemic times into account, but also to extend the criteria of the quality of donor organs. The requirements for a reliable preservation method are, therefore, high. The clinical standard is the flushing of the pulmonary artery with Perfadex solution at 4°C. The aim of our project was to improve this method with the addition of CNI-1493 and compstatin, respectively. The experiments were performed using an isolated organ model.

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  1. Klinik für Herz-, Thorax- und Gefäßchirurgie, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland

    Ö. Senbaklavaci, H. Taspinar, M. Hartert, S. Keränen & C.F. Vahl

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  1. Ö. Senbaklavaci
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  2. H. Taspinar
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  3. M. Hartert
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  4. S. Keränen
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Correspondence to Ö. Senbaklavaci.

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Senbaklavaci, Ö., Taspinar, H., Hartert, M. et al. Ein tierexperimentelles Modell zur Verbesserung der Organkonservierung bei Lungentransplantation. Z Herz- Thorax- Gefäßchir 26, 133–136 (2012). https://doi.org/10.1007/s00398-011-0894-2

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  • DOI: https://doi.org/10.1007/s00398-011-0894-2

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