Zusammenfassung
Valide Studienergebnisse sind wesentliche Voraussetzung für Akzeptanz und erfolgreiches Praktizieren evidenzbasierter Chirurgie. Die angestrebte Validität ist jedoch ggf. durch verschiedene Formen systematischer Verzerrung (Bias) verringert.
In chirurgischen Studien sind vor allem Patientenselektion, Durchführung der Intervention sowie die Beurteilung relevanter Endpunkte anfällig für Bias. Ähnlich wie die „Sünde“ ist Bias potenziell omnipräsent, weshalb das Bias-Risiko lediglich kontrolliert, nicht aber vollständig eliminiert werden kann.
Dieser Übersichtsartikel soll Chirurginnen und Chirurgen den Begriff Bias und dessen Bedeutung für die eigene kritische Würdigung von Studienergebnissen vermitteln.
Abstract
Clinical research is of cardinal importance for evidence-based surgery. However, surgical research is susceptible to various forms of systematic deviation (bias), thus, leading to potentially distorted results and incorrect conclusions. In surgical studies patient selection, performance of the intervention as well as outcome detection and assessment are particularly prone to bias. Analogous to the human “deadly sins”, bias is potentially omnipresent and the risk of bias can only be minimized but not entirely eliminated.
The objective of this educational review is to provide surgeons with the essential skills and basic knowledge to understand the importance and tremendous impact of bias on study findings. It is hoped that this concise overview will enable the readers to critically appraise study results and improve implementation of findings into clinical practise.
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Herrle, F., Güller, U. Reihe Evidenzbasierte Chirurgie. Z Herz- Thorax- Gefäßchir 23, 235–242 (2009). https://doi.org/10.1007/s00398-009-0728-7
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DOI: https://doi.org/10.1007/s00398-009-0728-7