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Was der Herzchirurg schon immer über die Herz-Lungen-Maschine wissen wollte

What the cardiac surgeon always wanted to know about heart-lung machines

  • Kardiotechnik/EKZ
  • Published:
Zeitschrift für Herz-,Thorax- und Gefäßchirurgie Aims and scope

Zusammenfassung

Die Herz-Lungen-Maschine (HLM) wurde seit ihrer Einführung stetig weiterentwickelt und modifiziert. Trotz aller technischen Neuerungen und Sicherungseinrichtungen an einer modernen HLM treten während der Perfusion Probleme auf, die ein sofortiges und kompetentes Handeln des Kardiotechnikers und des Chirurgen erfordern. Kontinuierliche Kommunikation sowie gegenseitiges Verständnis zwischen Chirurg und Kardiotechniker sind essenziell und deshalb Voraussetzung für den reibungslosen Ablauf von extrakorporaler Zirkulation (EKZ) und auch Operation. Funktionsprinzip, technische Entwicklungen sowie Probleme von HLM und EKZ werden grundlegend dargestellt und näher betrachtet.

Abstract

The extracorporeal circulation (cardiopulmonary bypass, CPB) was first introduced for clinical use in 1953. Since then, CPB has improved significantly in all aspects (including reliability, safety, durability, etc.) due to technical innovations and application of research results into clinical practice. Despite the very high standard of the technical equipment and the safety monitoring devices, perfusion problems still occur and require fast and well-trained actions from both the perfusionist and the surgeon. Communication throughout the procedure, as well as mutual understanding of the needs of perfusionists and surgeons are prerequisites for every cardiac surgery procedure with CPB and are of utmost importance if sudden problems with extracorporeal circulation should come up. This review covers all aspects of CPB, knowledge which should be part of the training program of every cardiac surgeon.

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Literatur

  1. LeGallois JJC, Nancrede NC, Nancrede JC, Thomas M (1813) Experiments on the Principles of Life.

  2. McLean J (1916) The thromboplastic action of cephalin. Am J Physiol 41:250–257

    Google Scholar 

  3. Chargraff E, Olson KB (1937) Studies on the chemistry of blood coagulation. VI. Studies on the action of heparin and other coagulant effect in vivo. J Biol Chem 122:153–167

    Google Scholar 

  4. Bigelow WG, Lindsay WK, Greenwood WF (1950) Hypothermia: its possible role in cardiac surgery: an investigation of factors governing survival in dogs at low body temperature. Ann Surg 132:849–866

    Article  PubMed  CAS  Google Scholar 

  5. Frey M von, Gruber M (1885) Untersuchungen über den Stoffwechsel isolierter Organe. Ein Respirations-Apparat für isolierte Organe. Virchow’s Arch Physiol 9:519

    Google Scholar 

  6. Gibbon JH Jr, Dobell AR, Voigt GB, et al (1954) The closure of interventicular septal defects on dogs during open cardiotomy with the maintenance of the cardio-respiratory functions by a pump oxygenator. J Thorac Surg 28:235–240

    PubMed  Google Scholar 

  7. Kirklin JW, Dushane JW, Wood EH, et al (1955) Intracardiac surgery with the aid of a mechanical pump-oxygenator system (Gibbon-type). Report of eight cases. Proc Mayo Clin 30:201–206

    CAS  Google Scholar 

  8. Deng MC, Wiedner M, Erren M, Mollhoff T, Assmann G, Scheld HH (1995) Arterial and venous cytokine response to cardiopulmonary bypass for low risk CABG and relation to hemodynamics. Eur J Cardiothorac Surg 9(1):22–29

    Article  CAS  Google Scholar 

  9. Göritz S, Schelkle H, Rein JG, Urbanek S (2006) Dynamic bubble trap can replace filter during cardiopulmonary bypass surgery. Perfusion 21:367–371

    Article  PubMed  Google Scholar 

  10. Perthel M, Kseibi S, Bendisch A, Laas J (2003) The dynamic bubble trap reduces microbubbles in extracorporeal circulation and high intensity transient signals in the middle cerebral artery: a case report. Perfusion 18(5):325–329

    Article  PubMed  Google Scholar 

  11. Schönburg M, Urbanek P, Erhardt G, Kraus B, Taborski U, Muhling A, Hein S, Roth M, Tiedtke HJ, Klovekorn WP (2001) Significant reduction of air microbubbles with the dynamic bubble trap during cardiopulmonary bypass. Perfusion 16(1):19–25

    Article  PubMed  Google Scholar 

  12. Hahn A., Sieburg F (2007) Herz-Lungen-Maschinen (HLM). In: Kramme R. Medizintechnik. Springer Heidelberg, S 463–482

  13. Utley JR (1990) Pathophysiology of cardiopulmonary bypass: current issues. J Card Surg 5(3):177–189

    Article  PubMed  CAS  Google Scholar 

  14. Fransen E, Maessen J, Dentener M, Senden N, Geskes G, Buurman W (1998) Systemic inflammation present in patients undergoing CABG without extracorporal circulation. Chest 113(5):1290–1295

    Article  PubMed  CAS  Google Scholar 

  15. Butler J, Rocker GM, Westaby S (1993) Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 55(2):552–559

    CAS  Google Scholar 

  16. Schönburg M, Kraus B, Muehling A, Taborski U, Hofmann H, Erhardt G, Hein S, Roth M, Vogt PR, Karliczek GF, Kloevekorn WP (2003) The dynamic air bubble trap reduces cerebral microembolism during cardiopulmonary bypass. J Thorac Cardiovasc Surg 126(5):1455–1460

    Article  Google Scholar 

  17. Mitchell S, Gorman D (2002) Air Embolism Pathophysiology The pathophysiology of cerebral arterial gas embolism. J Extra Corpor Technol. 34(1):18–23

    PubMed  Google Scholar 

  18. Tokuda Y, Song MH, Ueda Y, Usui A, Akita T, Yoneyama S, Maruyama S (2008) Three-dimensional numerical simulation of blood flow in the aortic arch during cardiopulmonary bypass. Eur J Cardiothorac Surg 33(2):164–167

    Article  PubMed  Google Scholar 

  19. Colangelo N, Torracca L, Lapenna E, Moriggia S, Crescenzi G, Alfieri O (2006) Vacuum-assisted venous drainage in extrathoratic cardiopulmonary bypass management during minimally invasive cardiac surgery. Perfusion 21(6):361–365

    Article  PubMed  Google Scholar 

  20. Perthel M, Kseibi S, Bendisch A, Laas J (2005) Use of dynamic bubble trap in the arterial line reduces microbubbles during cardiopulmonary bypass and microembolic signals in the middle cerebral artery. Perfusion 20(3):151–156

    Article  PubMed  Google Scholar 

  21. De Somer F (2007) Optimization of the perfusion circuit and its impact on the inflammatory response. J Extra Corpor Technol 39(4):285–288

    PubMed  Google Scholar 

  22. Mueller XM, Tevaearai HT, Horisberger J, Augstburger M, Boone Y, von Segesser LK (2001) Smart suction device for less blood trauma: a comparison with Cell Saver. Eur J Cardiothorac Surg. 19(4):507–511

    Article  PubMed  CAS  Google Scholar 

  23. Cremer J, Martin M, Redl H, Bahrami S, Abraham C, Graeter T, Haverich A, Schlag G, Borst HG (1996) Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg 61(6):1714–1720

    Article  CAS  Google Scholar 

  24. Taylor KM (1996) SIRS-The systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg 61(6):1607–1608

    CAS  Google Scholar 

  25. Boeken U, Feindt P (2008) Ist das SIRS/Sepsis-Syndrom in der Herzchirurgie Folge der extrakorporalen Zirkulation und damit unvermeidlich? Z Herz-, Thorax- Gefäßchir 22:110–118

    Article  Google Scholar 

  26. Nyawo B, Botha P, Pillay T, Clark SC, Tocewicz K, Forty J, Hamilton JR, Hill P, Hasan A (2008) Clinical experience with assisted venous drainage cardiopulmonary bypass in elective cardiac reoperations. Heart Surg Forum 11(1):21–23

    Article  Google Scholar 

  27. Scharfschwerdt M, Richter A, Boehmer K, Repenning D, Sievers HH (2004) Improved hydrodynamics of a new aortic cannula with a novel tip design. Perfusion 19(3):193–197

    Article  PubMed  Google Scholar 

  28. Edmunds LH Jr (2002) The evolution of cardiopulmonary bypass: lessons to be learned. Perfusion 17(4):243–251

    Article  PubMed  Google Scholar 

  29. Skrabal CA, Khosravi A, Choi YH, Kaminski A, Westphal B, Steinhoff G, Liebold A (2006) Pericardial suction blood separation attenuates inflammatory response and hemolysis after cardiopulmonary bypass. Scand Cardiovasc J 40(4):219–223

    Article  PubMed  Google Scholar 

  30. Pierangeli A, Masieri V, Bruzzi F, De Toni E, Grillone G, Boni P, Delnevo A. (2001) Hemolysis during cardiopulmonary bypass: how to reduce the free hemoglobin by managing the suctioned blood separately. Perfusion 16(6):519–524

    PubMed  CAS  Google Scholar 

  31. Ueyama K, Nishimura T, Nishina T, Nakamura T, Ikeda T, Komeda M (2004) PMEA coating of pump circuit and oxygenator may attenuate the early systemic inflammatory response in cardiopulmonary bypass surgery ASAIO J 50(4):369–372

    PubMed  CAS  Google Scholar 

  32. Skrabal CA, Khosravi A, Westphal B, Steinhoff G, Liebold A (2006) Effects of poly-2-methoxyethylacrylate (PMEA)-coating on CBP circuits. Scand Cardiovasc J 40(4):224–229

    Article  CAS  Google Scholar 

  33. Pappalardo F, Della Valle P, Crescenzi G, Corno C, Franco A, Torracca L, Alfieri O, Galli L, Zangrillo A, D’Angelo A (2006) Phosphorylcholine coating may limit thrombin formation during high-risk cardiac surgery: a randomized controlled trial. Ann Thorac Surg 81(3):886–891

    Article  Google Scholar 

  34. Gunaydin S (2004) Clinical significance of coated extracorporeal circuits: a review of novel technologies. Perfusion 19 Suppl 1:33–41

    Article  Google Scholar 

  35. Shann KG, Likosky DS, Murkin JM, Baker RA, Baribeau YR, DeFoe GR, Dickinson TA, Gardner TJ, Grocott HP, O’Connor GT, Rosinski DJ, Sellke FW, Willcox TW (2006) An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response. J Thorac Cardiovasc Surg. Aug;132(2):283–290

    Article  PubMed  Google Scholar 

  36. Ginther R Jr, Fillingham R, Rearles B, Darling E (2003) Department use of crisis management drills: survey results. Perfusion 18(5):229–302

    Article  Google Scholar 

  37. Stock UA, Müller T, Bienek R, Krause H, Hartrumpf M, Albes J (2006) Deairing of the venous drainage in standard extracorporeal circulation results in a profound reduction of arterial micro bubbles. Thorac Cardiovasc Surg 54(1):39–41

    CAS  Google Scholar 

  38. Graves K (2005) Perfusion safety in Europe: managing risks, learning from mistakes. Perfusion 20(4):209–215

    Article  PubMed  CAS  Google Scholar 

  39. Andersen MN, Ringgaard S, Hasenkam JM, Nygaard H (2004) Quantitative haemodynamic evaluation of aortic cannulas. Perfusion 19(5):323–330

    Article  PubMed  Google Scholar 

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Correspondence to Christoph Benk.

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Dipl.-Ing. Christoph Benk, Jahrgang 1974, absolvierte das Studium Medical Engineering mit dem Schwerpunkt OP-Ingenieur an der Fachhochschule Furtwangen. Er arbeitet seit 2003 als leitender Kardiotechniker am Universitätsklinikum Freiburg und ist wissenschaftlicher Leiter der deutschen Gesellschaft für Kardiotechnik. Seit 2004 hat er einen Lehrauftrag im Fach Spezielle Kardiotechnik an der Fachhochschule Furtwangen.

Interessenkonflikt. Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Benk, C., Klemm, R., Schaller, S. et al. Was der Herzchirurg schon immer über die Herz-Lungen-Maschine wissen wollte. Z Herz- Thorax- Gefäßchir 22, 237–244 (2008). https://doi.org/10.1007/s00398-008-0644-2

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  • DOI: https://doi.org/10.1007/s00398-008-0644-2

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