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Contemporary modeling and analysis of steady state and transient human blood rheology

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Abstract

The rheological characterization of a human blood, through modeling and analysis of transient flows and large-amplitude oscillatory shear (LAOS) flow, has made tremendous progress recently. We show how various components, and modifications of two recent scalar, structural kinetic, thixotropic models, can offer several modeling and prediction improvements, and compare our results to the Maxwell-like Bautista-Manero-Puig (BMP) model, and a recent transient model based on the Herschel-Bulkley. We explore the weakness of the legacy blood models, and then, we apply this newly improved model to recently published data from the literature in order to demonstrate its efficacy in modeling steady state, transient, and oscillatory shear flow. Following this effort, we demonstrate a novel approach using the sequence of physical phenomena (SPP) to facilitate interpretation, characterization, mapping, and “fingerprinting” of transient blood data from the literature. We compare the SPP approach to other LAOS analysis techniques in the literature and show how our approach can function as a mechanical-property diagnostic blood analysis tool. The goal of this work is a deeper understanding of the microstructural basis and validity of structural thixotropic blood models, and transient flow analysis techniques and procedures.

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Acknowledgements

The authors acknowledge the support funding assistance from the US Army and the Department of Chemistry and Life Science, United States Military Academy. The authors also acknowledge support in the form of helpful and insightful discussions with Jeff Horner, Dr. Antony Beris, and Dr. Norman Wagner from the University of Delaware, as well as Dr. Simon Rogers from the University of Illinois Urbana-Champaign. The views expressed herein are those of the authors and do not reflect the position of the United States Military Academy, the Department of the Army, or the Department of Defense. Sousa et al. (2013) and Moreno et al. (2015) data reprinted with permission of corresponding author, respectively.

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  1. Michael Clarion, Michael Deegan, Tyler Helton, Jesse Hudgins, Nick Monteferrante, Evan Ousley & Matthew Armstrong

    Present address: Department of Chemistry and Life Science, United States Military Academy, West Point, NY, 10996, USA

Authors and Affiliations

  1. Uniformed University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA

    Michael Clarion

  2. Creighton University School of Medicine, Omaha, NE, 68102, USA

    Nick Monteferrante

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  1. Michael Clarion
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Correspondence to Matthew Armstrong.

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Clarion, M., Deegan, M., Helton, T. et al. Contemporary modeling and analysis of steady state and transient human blood rheology. Rheol Acta 57, 141–168 (2018). https://doi.org/10.1007/s00397-017-1062-8

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