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Effect of tube diameter and capillary number on platelet margination and near-wall dynamics

Rheologica Acta volume 55, pages 511–526 (2016)Cite this article

Abstract

I investigate the effect of tube diameter D and red blood cell capillary number C a (i.e. the ratio of viscous to elastic forces) on platelet margination in blood flow at ≈37 % tube haematocrit. The system is modelled as three-dimensional suspension of deformable red blood cells and nearly rigid platelets using a combination of the lattice-Boltzmann, immersed boundary and finite element methods. Results of simulations during the dynamics before the steady state has been reached show that a non-diffusive radial platelet transport facilitates margination. This non-diffusive effect is important near the edge of the cell-free layer, but only for C a > 0.2, when red blood cells are tank-treading. I also show that platelet trapping in the cell-free layer is reversible for C a ≤ 0.2. Margination is essentially independent of C a only for the smallest investigated tube diameter (D = 10 μm). Once platelets have reached the cell-free layer, they tend to slide rather than tumble. The tumbling rate is essentially independent of C a but increases with D. Strong confinement suppresses tumbling due to the relatively small cell-free layer thickness at ≈ 37 % tube haematocrit.

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Acknowledgments

I acknowledge the award of a Chancellor’s Fellowship from the University of Edinburgh and computer resources at Eindhoven University of Technology. I also thank the three anonymous reviewers for their constructive suggestions that led to an improved manuscript and Gary B. Davies for suggestions to improve the language. There is no conflict of interest. Figures have been created with TikZ and ParaView.

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  1. School of Engineering, The University of Edinburgh, Edinburgh, EH9 3JL, UK

    Timm Krüger

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Correspondence to Timm Krüger.

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This paper belongs to the special issue on the “Rheology of blood cells, capsules and vesicles”

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Krüger, T. Effect of tube diameter and capillary number on platelet margination and near-wall dynamics. Rheol Acta 55, 511–526 (2016). https://doi.org/10.1007/s00397-015-0891-6

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Keywords

  • Platelet margination
  • Red blood cell
  • Cell-free layer
  • Lattice-Boltzmann method
  • Immersed boundary method
  • Simulation