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Rheological and diffusion properties of a dextran-con A polymer in the presence of Insulin and Magnesium

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An Erratum to this article was published on 18 October 2006

Abstract

Previous work carried out in our laboratories has focused on the formation and investigation of a dextran and concanavalin A (con A) based gel, which has the ability to alter its conformational structure in the presence and absence of free and terminal glucoses such that a gel–sol phase transition occurs. Here we report the diffusion and rheological investigations in to the effects of the addition of insulin and varyingconcentrations of magnesium chloride hexahydrate (Mg2Cl26H2O) at 20 and 37 °C. Rheological examination of glucose-sensitive (dextran-con A) gels were conducted using a cone and plate viscometer used in continual rotation and oscillatory modes. The results are interpreted in terms of the structure of the gel network and suggest rheological assessment provides an effective method of assessing the properties of gel systems. The subsequent testing of such formulations in in-vitro diffusion experiments revealed a reduction in the rate of diffusivity in the insulin marker, poly R-478 dye. The performance of this self-regulating drug delivery system has been examined and the addition of insulin and magnesium chloride may alter the way in which the gel operates as a drug delivery device and in the delivery of insulin. This may have implications for other ligands.

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Acknowledgements

The authors would like to thank the Edith Murphy Foundation for support. We would also like to express thanks to Professor Stephen Harding for his advice and support

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Authors and Affiliations

  1. Insulin Diabetes Experimental Research Group, Faculty of Medicine and Health Science, University of Nottingham, Clifton Boulevard, NG7 2UH, UK

    Gary G. Adams & Yuxin Cui

  2. Division of Food Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough Leics, LE12 5RD, UK

    John H. Mitchell

  3. Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LEI 9BH, UK

    M. Joan Taylor

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  1. Gary G. Adams
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  2. Yuxin Cui
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  3. John H. Mitchell
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  4. M. Joan Taylor
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Corresponding author

Correspondence to Gary G. Adams.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00397-006-0132-0.

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Adams, G.G., Cui, Y., Mitchell, J.H. et al. Rheological and diffusion properties of a dextran-con A polymer in the presence of Insulin and Magnesium. Rheol Acta 45, 611–620 (2006). https://doi.org/10.1007/s00397-005-0013-y

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  • DOI: https://doi.org/10.1007/s00397-005-0013-y

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