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Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

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Abstract

A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

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Authors and Affiliations

  1. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130–650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, , , , , , KR

    K. Y. Lee, J.-H. Kim, I. C. Kwon & S. Y. Jeong

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  1. K. Y. Lee
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  2. J.-H. Kim
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  3. I. C. Kwon
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  4. S. Y. Jeong
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Received: 24 April 2000/Accepted: 11 July 2000

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Lee, K., Kim, JH., Kwon, I. et al. Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin. Colloid Polym Sci 278, 1216–1219 (2000). https://doi.org/10.1007/s003960000389

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  • DOI: https://doi.org/10.1007/s003960000389

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