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Co-micellization conduct and structural dynamics of block copolymers in water and salt solution environment for drug solubilization enhancement

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Abstract

The present study examines the co-micellization in different block copolymers (BCPs): P123 and F127 (with almost similar hydrophobic PO block but different hydrophilic %EO content). In varying concentration and in presence of NaCl, these BCP solutions in single and mix system displayed a variety of phases, i.e., blue point (BP), thermoreversible gel formation and cloud point (CP) with a noticeable sol–gel phase transition shift. The nanoscale micellar size distribution expressed as hydrodynamic diameter (Dh) was evaluated using dynamic light scattering (DLS). As F127 is larger than P123 and contains more EO groups, the micelle corona appears larger with greater Dh. The scattering profile from small-angle x-ray scattering (SAXS) offered information into the micellar dimensions employing SasView 4.2.2 program. The quercetin (QCT) solubilization articulated in encapsulation efficiency (EE%) and drug loading (DL%) followed the enhancement order: P123 > (P123 + F127) > F127 which was inferred from spectral and microscopy study.

Graphical Abstract

5%w/v Pluronics® (P123 and F127) in single (pure) and mix environment depicting their micellar dimensions obtained from SAXS.

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Acknowledgements

The authors acknowledge Sardar Vallabhbhai National Institute of Technology (SVNIT), Gujarat, India for providing the instrumentation facilities.

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Authors and Affiliations

  1. Department of Chemistry, Sardar Vallabhbhai National Institute of Technology (SVNIT), Ichchhanath, Surat, Gujarat, 395 007, India

    Divya Patel & Ketan Kuperkar

  2. Chemistry Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai, Maharashtra, 400 085, India

    Santosh L. Gawali & Puthusserickal A. Hassan

  3. Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, Maharashtra, 400094, India

    Santosh L. Gawali & Puthusserickal A. Hassan

  4. Department of Chemistry, Veer Narmad South Gujarat University (VNSGU), Udhana-Magdalla road, Surat, Gujarat, 395 007, India

    Pratap Bahadur

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  1. Divya Patel
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Correspondence to Ketan Kuperkar.

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Patel, D., Gawali, S.L., Kuperkar, K. et al. Co-micellization conduct and structural dynamics of block copolymers in water and salt solution environment for drug solubilization enhancement. Colloid Polym Sci 301, 919–931 (2023). https://doi.org/10.1007/s00396-023-05109-x

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