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Preparation of hollow silica nanoparticles using cationic spherical polyelectrolyte brushes as catalytic template

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Abstract

This paper presents a facile procedure to fabricate uniform-sized hollow silica nanoparticles (SNP) under a mild condition by using cationic spherical polyelectrolyte brushes (SPB) with a polystyrene (PS) core and densely grafted poly(2-aminoethyl methacrylate hydrochloride) (PAEMH) brush shell as a catalytic template. By changing the brush layer thickness of SPB, hollow SNP with different silica shell thickness could be easily obtained. This method provides a new way for the preparation of hollow SNP without additional catalyst. The obtained hollow SNP exhibited a high-drug encapsulation efficiency (80%) for doxorubicin hydrochloride (DOX), should be of significance in the fields of drug delivery, cancer therapy, and bioimaging.

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Funding

This work is financially supported by the NSFC (Grant nos.51761135128 and 51773061), the Key Scientific and Technological Project of Xinjiang Bingtuan (2018AB025), and the Fundamental Research Funds for the Central Universities (22221818010 and 222201917013).

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Author notes

  1. Zhinan Fu and Qian Zhou contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Chemical Engineering, Engineering Research Center of Large Scale Reactor Engineering and Technology (Ministry of Education), and International Joint Research Center of Green Energy Chemical Engineering, East China University of Science and Technology, 200237, Shanghai, People’s Republic of China

    Zhinan Fu, Qian Zhou, Li Li, Dianhua Liu & Xuhong Guo

  2. Engineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, 832000, Xinjiang, People’s Republic of China

    Xuhong Guo

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  1. Zhinan Fu
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  2. Qian Zhou
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  3. Li Li
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  5. Xuhong Guo
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Correspondence to Li Li.

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Fu, Z., Zhou, Q., Li, L. et al. Preparation of hollow silica nanoparticles using cationic spherical polyelectrolyte brushes as catalytic template. Colloid Polym Sci 298, 879–886 (2020). https://doi.org/10.1007/s00396-020-04627-2

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  • DOI: https://doi.org/10.1007/s00396-020-04627-2

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