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Structural dynamics of tween-based microemulsions for antimuscarinic drug mirabegron

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Abstract

Microemulsions (μEs)-based drug delivery is known to be superior as well as effective due to customizable and easy management, efficiency and capability, and quick drug absorption over a wide range of targets. Herein, two μE formulations were established comprising of clove oil (as oil phase), water (as aqueous phase), Tween-80 (as surfactant), isopropanol, and methanol (as cosurfactant) for formulation A (μE-A) and formulation B (μE-B), respectively, and further used for the encapsulation of an antimuscarinic drug, mirabegron (MBG). Multiple complementary measurements, namely, electrical conductivity (σ), viscosity (η), and optical microscopy, show the existence of phase transition from W/O to O/W μE via intermediate bicontinuous channels. MBG showed long storage stability as well as good solubility i.e. 3.0 and 2.5 wt% at pH 6.4 in optimum μE-A and μE-B, respectively. Furthermore, no apparent aggregation of MBG was observed, as revealed by scanning transmission electron microscopy and peak correlations of IR analysis, suggesting the stability of MBG inside the formulations. Likewise, fluorescence detection senses the interfacial environment of MBG molecules in the examined formulations that could be vital for understanding the mechanism of controlled drug release.

Structural Dynamics of Tween-Based Microemulsions for Antimuscarinic Drug Mirabegron

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Acknowledgements

The authors express their gratitude to the Department of Chemistry, University of Gujrat Pakistan for providing laboratory facilities.

Funding

M.F. Nazar also extends his thanks to Higher Education Commission of Pakistan for providing financial support through NRPU Project. 20–4557/NRPU/R&D/HEC/14/481.

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Authors and Affiliations

  1. Department of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan

    Muhammad Faizan Nazar, Ayesha Mujeed, Muhammad Yasir Siddique, Muhammad Atif Saleem, Muhammad Ashfaq, Sajjad Hussain Sumrra, Muhammad Zubair & Muhammad Nadeem Zafar

  2. Department of Biochemistry & Biotechnology, University of Gujrat, Gujrat, 50700, Pakistan

    Muddassar Zafar

  3. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

    Asad Muhammad Khan

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  1. Muhammad Faizan Nazar
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Correspondence to Muhammad Faizan Nazar.

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Nazar, M.F., Mujeed, A., Siddique, M.Y. et al. Structural dynamics of tween-based microemulsions for antimuscarinic drug mirabegron. Colloid Polym Sci 298, 263–271 (2020). https://doi.org/10.1007/s00396-020-04603-w

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