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CTAB-assisted fabrication of well-shaped PDA-based colloidosomes

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Abstract

Colloidosomes have gained intensive attention in the past years due to their substantial applications in wide scopes involving encapsulation, catalysis, and drug delivery, etc. In this study, we depicted the templated fabrication of well-shaped colloidosomes with tunable shell thickness by Pickering emulsion at a mild condition. To this end, toluene-in-water Pickering emulsion stabilized by cetyltrimethylammonium bromide (CTAB)–modified polydopamine (PDA) nanoparticles (PDA@CTAB) was prepared. After the covalent cross-linking of PDA nanoparticles assembled on the surface of an oil droplet through chemical reactions occurring in toluene phase, exclusive intra-colloidosomes were afforded. The shell thickness of colloidsomes could be roughly tuned by the adjustment of the amount of the reactive monomers in the oil phase. Our investigations revealed that CTAB was critical for the successful fabrication of well-shaped colloidosomes. Otherwise, only irregular structures were obtained if pristine PDA–stabilized Pickering emulsion was applied. The current strategy could enable hydrophobic cargo, such as 10-hydroxycamptothecin to be encapsulated while colloidosomes were created. The release behavior of the encapsulated cargoes was also investigated.

CTAB was necessary for the templated fabrication of well-shaped colloidosomes by PDA-stabilized oil-in-water Pickering emulsion

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Funding

The authors thank the financial supports from the National Natural Science Foundation of China (21574112) and the Project of Xiangtan University (2017XZZ36).

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Authors and Affiliations

  1. Key Laboratory of Alternative Technologies for Fine Chemicals Process of Zhejiang Province, College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, Zhejiang Province, China

    Pin Liu, Chenze Qi & Yong Gao

  2. College of Chemistry, Key Lab of Environment-friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, Hunan Province, China

    Pin Liu & Yong Gao

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  1. Pin Liu
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  2. Chenze Qi
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Correspondence to Yong Gao.

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Liu, P., Qi, C. & Gao, Y. CTAB-assisted fabrication of well-shaped PDA-based colloidosomes. Colloid Polym Sci 297, 1301–1311 (2019). https://doi.org/10.1007/s00396-019-04547-w

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  • DOI: https://doi.org/10.1007/s00396-019-04547-w

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