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Au nanoparticles coated with chitosan

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Abstract

This paper describes a method of coating metallic gold (Au) nanoparticles with chitosan (CS) shells in an aqueous solution. A colloidal solution of Au nanoparticles with a particle size of 16.5 ± 1.7 nm was prepared by reducing the Au ions (III) with sodium citrate in water at 80 °C. CS coating was achieved in an aqueous solution containing the Au nanoparticles by using CS as a shell source and sodium hydroxide as a pH adjuster at 25 °C. Ultraviolet-visible extinction spectroscopy and transmittance electron microscopy observation revealed that the Au nanoparticles were coated with CS shells. Additionally, the CS shell thickness could be varied in a range up to 2.2 nm by changing the CS concentration during the CS-coating process.

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References

  1. El-Gamal FE-ZA, Elmogy M, Atwan A (2016) Current trends in medical image registration and fusion. Egypt Inform J 17:99–124

    Article  Google Scholar 

  2. Garland M, Yim JJ, Bogyo M (2016) A bright future for precision medicine: advances in fluorescent chemical probe design and their clinical application. Cell Chem Biol 23:122–136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Bagheri MH, Ahlman MA, Lindenberg L, Turkbey B, Lin J, Civelek AC, Malayeri AA, Agarwal PK, Choyke PL, Folio LR, Apolo AB (2017) Advances in medical imaging for the diagnosis and management of common genitourinary cancers. Urol Oncol 35:473–491

    Article  PubMed  PubMed Central  Google Scholar 

  4. Caschera L, Lazzara A, Piergallini L, Ricci D, Tuscano B, Vanzulli (2016) A contrast agents in diagnostic imaging: present and future. Pharmacol Res 110:65–75

    Article  CAS  PubMed  Google Scholar 

  5. Hameed S, Dai Z (2018)Near-infrared fluorescence probes for surgical navigation. Mater Today Chem 10:90–103

    Article  CAS  Google Scholar 

  6. Elahi N, Kamali M, Baghersad MH (2018) Recent biomedical applications of gold nanoparticles: a review. Talanta 184:537–556

    Article  CAS  PubMed  Google Scholar 

  7. Narmani A, Farhood B, Haghi-Aminjan H, Mortezazadeh T, Aliasgharzadeh A, Mohseni M, Najafi M, Abbasi H (2018) Gadolinium nanoparticles as diagnostic and therapeutic agents: their delivery systems in magnetic resonance imaging and neutron capture therapy. J Drug Deliv Sci Technol 44:457–466

    Article  CAS  Google Scholar 

  8. Liu B, Jiang B, Zheng Z, Liu T (2019) Semiconductor quantum dots in tumor research. J Lumin 209:61–68

    Article  CAS  Google Scholar 

  9. Carnovale C, Bryant G, Shukla R, Bansal V (2016) Size, shape and surface chemistry of nano-gold dictate its cellular interactions, uptake and toxicity. Prog Mater Sci 83:152–190

    Article  CAS  Google Scholar 

  10. Missaoui WN, Arnold RD, Cummings BS (2018) Toxicological status of nanoparticles: what we know and what we don’t know. Chem Biol Interact 295:1–12

    Article  CAS  PubMed  Google Scholar 

  11. Telgmann L, Sperling M, Karst U (2013) Determination of gadolinium-based MRI contrast agents in biological and environmental samples: a review. Anal Chim Acta 764:1–16

    Article  CAS  PubMed  Google Scholar 

  12. Yang Y, Yu C (2016) Advances in silica based nanoparticles for targeted cancer therapy. Nanomedicine 12:317–332

    Article  CAS  PubMed  Google Scholar 

  13. Diab R, Canilho N, Pavel IA, Haffner FB, Girardon M, Pasc A (2017)Silica-based systems for oral delivery of drugs, macromolecules and cells. Adv Colloid Interf Sci 249:346–362

    Article  CAS  Google Scholar 

  14. Bagheri E, Ansari L, Abnous K, Taghdisi SM, Charbgoo F, Ramezani M, Alibolandi M (2018) Silica based hybrid materials for drug delivery and bioimaging. J Control Release 277:57–76

    Article  CAS  PubMed  Google Scholar 

  15. Kobayashi Y, Imai J, Nagao D, Takeda M, Ohuchi N, Kasuya A, Konno M (2007) Preparation of multilayered silica-Gd-silicacore-shell particles and their magnetic resonance images. Colloids Surf A Physicochem Eng Asp 308:14–19

    Article  CAS  Google Scholar 

  16. Muxika A, Etxabide A, Uranga J, Guerrero P, de la Caba K (2017) Chitosan as a bioactive polymer: processing, properties and applications. Int J Biol Macromol 105:1358–1368

    Article  CAS  PubMed  Google Scholar 

  17. Zhu G-T, Hu X-L, He S, He X-M, Zhu S-K, Feng Y-Q(2018) Hydrothermally tailor-made chitosan fiber for micro-solid phase extraction of petroleum acids in crude oils. J Chromatogr A 1564:42–50

    Article  CAS  PubMed  Google Scholar 

  18. Naskar S, Sharma S, Kuotsu K (2019)Chitosan-based nanoparticles: an overview of biomedical applications and its preparation. J Drug Deliv Sci Technol 49:66–81

    Article  CAS  Google Scholar 

  19. Omidi S, Kakanejadifard A (2019) Modification of chitosan and chitosan nanoparticle by long chain pyridinium compounds: synthesis, characterization, antibacterial, and antioxidant activities. Carbohydr Polym 208:477–485

    Article  CAS  PubMed  Google Scholar 

  20. Shariatinia Z (2019) Pharmaceutical applications of chitosan. Adv Colloid Interf Sci 263:131–194

    Article  CAS  Google Scholar 

  21. Chen R, Wang X, Yao X, Zheng X, Wang J, Jiang X (2013)Near-IR-triggeredphotothermal/photodynamicdual-modality therapy system via chitosan hybrid nanospheres. Biomaterials 34:8314–8322

  22. Zeng W, Liu Z, Li Y, Zhu S, Ma J, Li W, Gao G (2017) Development and characterization of cores-shell poly (lactide-co-glycolide)-chitosan microparticles for sustained release of GDNF. Colloids Surf B 159:791–799

    Article  CAS  Google Scholar 

  23. Bagheri M, Younesi H, Hajati S, Borghei SM (2015) Application of chitosan-citric acid nanoparticles for removal of chromium (VI). Int J Biol Macromol 80:431–444

    Article  CAS  PubMed  Google Scholar 

  24. Dey A, Kamat A, Nayak S, Danino D, Kesselman E, Dandekar P, Jain R (2018) Role of proton balance in formation of self-assembled chitosan nanoparticles. Colloids Surf B 166:127–134

    Article  CAS  Google Scholar 

  25. Saad AHA, Azzam AM, El-Wakeel ST, Mostafa BB, El-latif MBA (2018) Removal of toxic metal ions from wastewater using ZnO@chitosan core-shell nanocomposite. Environ Nanotechnol Monit Manage 9:67–75

    Google Scholar 

  26. Liz-Marzán LM, Giersig M, Mulvaney P (1996) Synthesis of nanosized gold-silica core-shell particles. Langmuir 12:4329–4335

    Article  Google Scholar 

  27. Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A (2011) Control of shell thickness in silica-coating of au nanoparticles and their X-ray imaging properties. J Colloid Interface Sci 358:329–333

    Article  CAS  PubMed  Google Scholar 

  28. Kobayashi Y, Nagasu R, Shibuya K, Nakagawa T, Kubota Y, Gonda K, Ohuchi N (2014) Synthesis of a colloid solution of silica-coated gold nanoparticles for X-ray imaging applications. J Nanopart Res 16:2551

    Article  CAS  Google Scholar 

  29. Liu N, Wang K, Gao Y, Li D, Lin W, Li C (2017) Tartrate as a substitute of citrate to prepare gold colloids from chloroauric acid. Colloids Surf A Physicochem Eng Asp 535:251–256

    Article  CAS  Google Scholar 

  30. Salabat A, Mirhoseini F (2018) A novel and simple microemulsion method for synthesis of biocompatible functionalized gold nanoparticles. J Mol Liq 268:849–853

    Article  CAS  Google Scholar 

  31. Parveen R, Ullah S, Sgarbi R, Tremiliosi-Filho G (2019)One-pot ligand-free synthesis of gold nanoparticles: the role of glycerol as reducing-cum-stabilizing agent. Colloids Surf A Physicochem Eng Asp 565:162–171

    Article  CAS  Google Scholar 

  32. Lee J, Bartelt-Hunt SL, Li Y, Gilrein EJ (2016) The influence of ionic strength and organic compounds on nanoparticle TiO2 (n-TiO2) aggregation. Chemosphere 154:187–193

    Article  CAS  PubMed  Google Scholar 

  33. Wilkinson N, Metaxas A, Brichetto E, Wickramaratne S, Reineke TM, Dutcher CS (2017) Ionic strength dependence of aggregate size and morphology on polymer-clay flocculation. Colloids Surf A Physicochem Eng Asp 529:1037–1046

    Article  CAS  Google Scholar 

  34. Wu W, Song R, Xu Z, Jing Y, Dai H, Fang G (2018) Fluorescent cellulose nanocrystals with responsiveness to solvent polarity and ionic strength. Sensors Actuators B Chem 275:490–498

    Article  CAS  Google Scholar 

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Funding

This work was supported by JSPS KAKENHI Grant Numbers 24310085 and 16H05168.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Graduate School of Science and Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, Ibaraki, 316-8511, Japan

    Akitoshi Tokumasu, Tomoya Inose, Noriko Yamauchi, Kouichi Nakashima & Yoshio Kobayashi

  2. Department of Medical Physics, Graduate School of Medicine, Tohoku University, Sendai, Japan

    Tomoya Inose, Masayuki Tokunaga, Chihiro Kato & Kohsuke Gonda

  3. Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan

    Keiichiro Hatoyama & Takashi Kamei

Authors
  1. Akitoshi Tokumasu
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  2. Tomoya Inose
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  3. Noriko Yamauchi
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  4. Kouichi Nakashima
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  5. Masayuki Tokunaga
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  7. Keiichiro Hatoyama
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  8. Takashi Kamei
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  9. Kohsuke Gonda
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  10. Yoshio Kobayashi
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Correspondence to Noriko Yamauchi or Yoshio Kobayashi.

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Tokumasu, A., Inose, T., Yamauchi, N. et al. Au nanoparticles coated with chitosan. Colloid Polym Sci 297, 1143–1148 (2019). https://doi.org/10.1007/s00396-019-04524-3

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  • DOI: https://doi.org/10.1007/s00396-019-04524-3

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