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Structural characteristics of mPEG-PDLLA and their effects on micelle stability

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Abstract

The correlation between polymer microstructure of mPEG-PDLLA and secondary aggregation of its micelle was studied. Close examination of 1H NMR spectra revealed that the methine moieties, -CH(CH3)-, of mPEG-PDLLA polymer well represented its microstructure. To elucidate the physicochemical characteristics of various microstructures, we have developed an index, called L-ratio, to indicate the relative content of heterotactic component within the polymer. Storage stability of micelles from six polymers with different L-ratios (L-ratio ranging from 28 to 33%) was studied at 30 °C and 50 °C, and changes in average particle size were monitored to evaluate their secondary aggregation. We have found that polymers with high L-ratio takes longer time to secondary aggregation of polymeric micelles to occur. The findings should provide insightful guidance in the development of polymeric micelles.

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Acknowledgements

The authors thank Dr. Joonyoung Park for his discussion and proofreading during revision of the manuscript.

Funding

This study was supported by R&D fund of Samyang Biopharmaceutical Corporation and Grant 10047811 from Ministry of Trade, Industry and Energy (MOTIE, South Korea).

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Authors and Affiliations

  1. Samyang Biopharmaceuticals Corp, Pangyo-ro 295, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, South Korea

    Bumchan Min, Minhyo Seo, Bong Oh Kim, Youngjoo Koh, Yilwoong Yi & Hyerim Kim

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  1. Bumchan Min
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  2. Minhyo Seo
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  3. Bong Oh Kim
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Correspondence to Bumchan Min.

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Min, B., Seo, M., Kim, B.O. et al. Structural characteristics of mPEG-PDLLA and their effects on micelle stability. Colloid Polym Sci 297, 785–793 (2019). https://doi.org/10.1007/s00396-019-04495-5

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