Abstract
A novel drug carrier was synthesized through grafting polymerization of water-insoluble glucan from cotton cellulose tailored and polyoxyethylene oxide (PEO). By changing the molar ratio of water-insoluble glucan and ethylene oxide (EO), glucan-g-PEO copolymers with different chain lengths of PEO can be obtained. The physicochemical characteristics of docetaxel (DTX)-loaded glucan-g-PEO such as micro-morphology, size, critical micelle concentration (CMC), and in vitro release of kinetic were investigated. In vitro release profiles of docetaxel (DTX)-loaded glucan-g-PEO meet first-order release kinetics via a mechanism of diffusion and polymer chain relaxation. Another significant result is that release rates of DTX can be also modulated by changing the chain lengths of the PEO segments.
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Funding
This work was financially supported by the Tianjin Municipal Natural Science Foundation for Youth (no. 13JCQNJC05000), the Hebei Province Natural Science Foundation for Youth (no. B2015202306), the Young Foundation of Hebei Province (no. 2010122), the Natural Science Foundation of China (no. 21576064), and the Hebei Province Natural Science Foundation (no. B2016202290).
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Yang, F., Han, H., Fan, H. et al. Synthesis, characterization, and in vitro release analysis of a novel glucan-based polymer carrier. Colloid Polym Sci 296, 1401–1407 (2018). https://doi.org/10.1007/s00396-018-4354-3
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DOI: https://doi.org/10.1007/s00396-018-4354-3