Colloid and Polymer Science

, Volume 294, Issue 2, pp 399–407 | Cite as

Self-assembly of Novel Poly(d,l-Lactide-co-Glycolide)-b-Poly(N-Vinylpyrrolidone) (PLGA-b-PNVP) Amphiphilic Diblock Copolymers

  • K. Ramesh
  • Shikha Singh
  • Kheyanath Mitra
  • Dipankar Chattopadhyay
  • Nira Misra
  • Biswajit RayEmail author
Original Contribution


Alkyne-terminated poly(d,l-lactide-co-glycolide) (PLGA) has been synthesized via ROP at room temperature. Amphiphilic PLGA-b-poly(N-vinylpyrrolidone) (PNVP) block copolymers have been synthesized via alkyne-azide click reaction of it with azide-terminated PNVPs prepared by RAFT polymerization of NVP using an azide-terminated RAFT agent. 1H NMR and gel permeation chromatography (GPC) confirmed the formation of block copolymers. Self-assembly of these block copolymers was confirmed by fluorescence study using pyrene as a probe and supported by 1H NMR, DLS and TEM studies. Hydrophobic drug doxorubicin was successfully encapsulated at the micellar core of PLGA46-b-PNVP89 with drug-loading content (DLC) and drug-loading efficiency (DLE) of 10.8 and 43.2 %, respectively. Sustained drug release of these drug-loaded micelles was observed at both pH of 6.4 and 7.4. Faster drug release was observed at pH 6.4. Such PLGA-b-PNVP amphiphilic block copolymer may find extensive application in sustained drug delivery, specifically in antitumor drug delivery.


PLGA-b-PNVP RAFT Alkyne-azide click reaction 



Present work is supported by Department of Science Technology, New Delhi, India, under Nanomission project as well as by Department of Biotechnology (DBT), New Delhi, India, through the sanction no.BT/PR889/NNT/28/570/2011. K. Ramesh gratefully acknowledges Indian Institute of Technology (BHU), Varanasi, India, for Teaching Assistantship.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • K. Ramesh
    • 1
    • 2
  • Shikha Singh
    • 1
  • Kheyanath Mitra
    • 1
  • Dipankar Chattopadhyay
    • 3
  • Nira Misra
    • 2
  • Biswajit Ray
    • 1
    Email author
  1. 1.Department of Chemistry, Faculty of ScienceBanaras Hindu UniversityVaranasiIndia
  2. 2.School of Biomedical EngineeringIndian Institute of Technology (Banaras Hindu University)VaranasiIndia
  3. 3.Department of Polymer Science and TechnologyUniversity of CalcuttaKolkataIndia

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