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Encapsulation of paclitaxel in ultra-fine nanoparticles of acrylic/styrene terpolymer for controlled release

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Abstract

Paclitaxel (PTX) is one of the most utilized anticancer drugs with a broad spectrum of antitumor activity. PTX is usually formulated in Cremopher EL because it suffers from low solubility in water and has many side effects. Low solubility leads to encapsulation and controlled release of PTX being a rough process. In this study, a simple method was used for nano-encapsulation of PTX into three different types of ultra-fine polymeric particles. These include poly (methyl methacrylate) (PMMA), poly (styrene) (PST) and poly (methyl methacrylate-co-styrene) (P(MMA-ST-AA)) with several monomer ratios. Different drug contents in the monomer have been investigated. Synthesis was performed via the mini-emulsion polymerization method, and the results proved that PTX was encapsulated into spherical ultra-fine PA/PS nanoparticles of approximately 19 nm.

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Acknowledgments

The authors wish to thank Mr. Amin Imani for his useful discussions and Dr. Reza Kasrai for English editing.

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Authors and Affiliations

  1. Department of Materials and Polymer Engineering, Faculty of Engineering, University of Hakim Sabzevari, Sabzevar, Iran

    Ali Rajaee & Gholamali Farzi

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  1. Ali Rajaee
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  2. Gholamali Farzi
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Correspondence to Gholamali Farzi.

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Rajaee, A., Farzi, G. Encapsulation of paclitaxel in ultra-fine nanoparticles of acrylic/styrene terpolymer for controlled release. Colloid Polym Sci 294, 95–105 (2016). https://doi.org/10.1007/s00396-015-3752-z

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  • DOI: https://doi.org/10.1007/s00396-015-3752-z

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