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Self-assembly and paclitaxel loading capacity of α-tocopherol succinate-conjugated hydroxyethyl cellulose nanomicelle

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Abstract

A series of α-tocopherol succinate-conjugated hydroxyethyl cellulose (HEC-TOS) polymers were synthesized in this study. The weight percentages of TOS in HEC-TOS were varied from 15 to 36 % by adjusting the weight ratios of TOS to HEC from 1:4 to 5:2. The HEC-TOS polymers exhibited typical properties of amphiphilic polymers and were able to self-assemble into spherical nanomicelle in aqueous solution as revealed by TEM. The micelle sizes and critical micelle concentrations (CMC) of HEC-TOS conjugates were correlated with their molecular structures and were in the range of 24.5–115.1 nm and 16–99 μg/ml, respectively. Paclitaxel (PTX) was encapsulated into the core of HEC-TOS micelle by sonication-dialysis method. The highest loading concentration of PTX in micelle was 315 mg/ml, which was about 50 times higher than that in water (6 mg/l). The in vitro study showed that PTX was continuously released from PTX-loaded micelle in phosphate buffered saline (PBS) medium for 108 h.

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Acknowledgments

The authors gratefully acknowledge the financial support from the Open Foundation of the State Key Laboratory of Pulp and Papermaking Engineering, South China University of Technology (No. 201312); the Young Foundation of Dalian Polytechnic University (No. QNJJ201323); the National Science Foundation of China (No. 31170554; 51103046); and the China Education Ministry, Program for New Century Excellent Talents in University (NCET-13-0215).

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Authors and Affiliations

  1. Liaoning Key Laboratory of Pulp and Paper Engineering, Dalian Polytechnic University, Dalian, 116034, China

    Yanzhu Guo, Li Zhang, Haiming Li, Ying Han & Jinghui Zhou

  2. State Key Laboratory of Pulp and Papermaking Engineering, South China University of Technology, Guangzhou, 510640, China

    Yanzhu Guo & Xiaohui Wang

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  1. Yanzhu Guo
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  2. Li Zhang
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Correspondence to Jinghui Zhou or Xiaohui Wang.

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Guo, Y., Zhang, L., Li, H. et al. Self-assembly and paclitaxel loading capacity of α-tocopherol succinate-conjugated hydroxyethyl cellulose nanomicelle. Colloid Polym Sci 294, 135–143 (2016). https://doi.org/10.1007/s00396-015-3736-z

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  • DOI: https://doi.org/10.1007/s00396-015-3736-z

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